Quantitative Assessment of Vectorcardiographic Loop Morphology

Golriz Sedaghat, Elyar Ghafoori, Jonathan W. Waks, Muammar M. Kabir, Alexei Shvilkin, Mark E. Josephson, Larisa Tereshchenko

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Vectorcardiography (VCG), developed 100 years ago, characterizes clinically important electrophysiological properties of the heart. In this study, VCG QRS loop roundness, planarity, thickness, rotational angle, and dihedral angle were measured in 81 healthy control subjects (39.0 ± 14.2y; 51.8% male; 94% white), and 8 patients with infarct-cardiomyopathy and sustained monomorphic ventricular tachycardia (VT) (68.0 ± 7.8y, 37.5% male). The angle between two consecutive QRS vectors was defined as the rotational angle, while dihedral angle quantified planar alteration over the QRS loop. In VT subjects, planarity index decreased (0.63 ± 0.22 vs. 0.88 ± 0.10; P = 0.014), and dihedral angle was significantly more variable (variance of dihedral angle, median (IQR): 897(575-1450) vs. 542(343-773); P = 0.029; rMSSD: 47.7 ± 12.7 vs. 35.1 ± 13.1; P = 0.027). Abnormal electrophysiological substrate in VT patients is characterized by the appearance of QRS loop folding, likely due to local conduction block. The presence of fragmented QRS complexes on the 12-lead ECG had low sensitivity (31%) for detecting QRS loop folding on the VCG.

    Original languageEnglish (US)
    Pages (from-to)154-163
    Number of pages10
    JournalJournal of Electrocardiology
    Volume49
    Issue number2
    DOIs
    StatePublished - Mar 1 2016

    Fingerprint

    Vectorcardiography
    Ventricular Tachycardia
    Cardiomyopathies
    Healthy Volunteers
    Electrocardiography

    Keywords

    • Planarity
    • Vectorcardiography
    • Ventricular tachycardia

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Sedaghat, G., Ghafoori, E., Waks, J. W., Kabir, M. M., Shvilkin, A., Josephson, M. E., & Tereshchenko, L. (2016). Quantitative Assessment of Vectorcardiographic Loop Morphology. Journal of Electrocardiology, 49(2), 154-163. https://doi.org/10.1016/j.jelectrocard.2015.12.014

    Quantitative Assessment of Vectorcardiographic Loop Morphology. / Sedaghat, Golriz; Ghafoori, Elyar; Waks, Jonathan W.; Kabir, Muammar M.; Shvilkin, Alexei; Josephson, Mark E.; Tereshchenko, Larisa.

    In: Journal of Electrocardiology, Vol. 49, No. 2, 01.03.2016, p. 154-163.

    Research output: Contribution to journalArticle

    Sedaghat, G, Ghafoori, E, Waks, JW, Kabir, MM, Shvilkin, A, Josephson, ME & Tereshchenko, L 2016, 'Quantitative Assessment of Vectorcardiographic Loop Morphology', Journal of Electrocardiology, vol. 49, no. 2, pp. 154-163. https://doi.org/10.1016/j.jelectrocard.2015.12.014
    Sedaghat G, Ghafoori E, Waks JW, Kabir MM, Shvilkin A, Josephson ME et al. Quantitative Assessment of Vectorcardiographic Loop Morphology. Journal of Electrocardiology. 2016 Mar 1;49(2):154-163. https://doi.org/10.1016/j.jelectrocard.2015.12.014
    Sedaghat, Golriz ; Ghafoori, Elyar ; Waks, Jonathan W. ; Kabir, Muammar M. ; Shvilkin, Alexei ; Josephson, Mark E. ; Tereshchenko, Larisa. / Quantitative Assessment of Vectorcardiographic Loop Morphology. In: Journal of Electrocardiology. 2016 ; Vol. 49, No. 2. pp. 154-163.
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