Quantitative and Temporal Studies on Effect of Dexamethasone on Corticosterone Secretion in the Rat

John Kendall

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The rat corticosterone secretion rate determined fluorimetrically from 3-minute samples of adrenal effluent (123 ± 5.3 μg/kg/adrenal/hr) agrees well with values reported for more extended collection periods and analyzed by other methods. Dexamethasone-21-phosphate, a non-fluorescing, corticotropin-suppressing, synthetic steroid was found to produce maximal suppression of the corticosterone secretion rate 4 to 8 hours following a single dose. The technic described may be applied to assays of corticotropin itself or assays of corticotropin suppressing activity of other non-fluorescing agents.

Original languageEnglish (US)
Pages (from-to)926-928
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume107
Issue number4
DOIs
StatePublished - 1961
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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