Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis

Steven L. Jacques; Lisa A. Buckley; Scott A. Prahl; Kenton W.MD Gregory

Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis

Steven L. Jacques, Lisa A. Buckley, Scott A. Prahl, Kenton W.MD Gregory

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

PUVA therapy may prove effective in preventing restenosis of vessels following balloon angioplasty to open vessels narrowed by atherosclerosis. The technique relies on the ability of PUVA (psoralen administration followed by ultraviolet A irradiation) to cause crosslinks and monoadducts that prevent cellular proliferation without causing cell death. Such PUVA treatment has been successful in controlling cutaneous cell proliferation of psoriasis. The efficacy of PUVA treatment depends on the drug concentration and the light dose. The amount of light delivered is easily modified to adapt to variations in the drug concentration if the drug levels in the vessel wall are known. This paper demonstrates the feasibility of assaying psoralen levels in tissues and in serum samples using psoralen fluorescence as an indictor.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	George S. Abela
Pages	82-88
Number of pages	7
State	Published - 1994
Externally published	Yes
Event	Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV - Los Angeles, CA, USA Duration: Jan 22 1994 → Jan 23 1994

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2130
ISSN (Print)	0277-786X

Other

Other	Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV
City	Los Angeles, CA, USA
Period	1/22/94 → 1/23/94

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Cite this

Jacques, S. L., Buckley, L. A., Prahl, S. A., & Gregory, K. W. MD. (1994). Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. In G. S. Abela (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 82-88). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2130).

Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. / Jacques, Steven L.; Buckley, Lisa A.; Prahl, Scott A. et al.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / George S. Abela. 1994. p. 82-88 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2130).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jacques, SL, Buckley, LA, Prahl, SA & Gregory, KWMD 1994, Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. in GS Abela (ed.), Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 2130, pp. 82-88, Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV, Los Angeles, CA, USA, 1/22/94.

Jacques SL, Buckley LA, Prahl SA, Gregory KWMD. Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. In Abela GS, editor, Proceedings of SPIE - The International Society for Optical Engineering. 1994. p. 82-88. (Proceedings of SPIE - The International Society for Optical Engineering).

Jacques, Steven L. ; Buckley, Lisa A. ; Prahl, Scott A. et al. / Quantifying psoralen in tissues by fluorescence : dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. Proceedings of SPIE - The International Society for Optical Engineering. editor / George S. Abela. 1994. pp. 82-88 (Proceedings of SPIE - The International Society for Optical Engineering).

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Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis

Abstract

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