Quantifying psoralen in tissues by fluorescence

dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis

Steven Jacques, Lisa A. Buckley, Scott A. Prahl, Kenton Gregory

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

PUVA therapy may prove effective in preventing restenosis of vessels following balloon angioplasty to open vessels narrowed by atherosclerosis. The technique relies on the ability of PUVA (psoralen administration followed by ultraviolet A irradiation) to cause crosslinks and monoadducts that prevent cellular proliferation without causing cell death. Such PUVA treatment has been successful in controlling cutaneous cell proliferation of psoriasis. The efficacy of PUVA treatment depends on the drug concentration and the light dose. The amount of light delivered is easily modified to adapt to variations in the drug concentration if the drug levels in the vessel wall are known. This paper demonstrates the feasibility of assaying psoralen levels in tissues and in serum samples using psoralen fluorescence as an indictor.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsGeorge S. Abela
Pages82-88
Number of pages7
Volume2130
StatePublished - 1994
Externally publishedYes
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV - Los Angeles, CA, USA
Duration: Jan 22 1994Jan 23 1994

Other

OtherProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV
CityLos Angeles, CA, USA
Period1/22/941/23/94

Fingerprint

Dosimetry
dosimeters
vessels
drugs
Fluorescence
Irradiation
Tissue
fluorescence
irradiation
Balloons
Cell proliferation
Cell death
assaying
arteriosclerosis
balloons
death
serums
therapy
dosage
causes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Jacques, S., Buckley, L. A., Prahl, S. A., & Gregory, K. (1994). Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. In G. S. Abela (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2130, pp. 82-88)

Quantifying psoralen in tissues by fluorescence : dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. / Jacques, Steven; Buckley, Lisa A.; Prahl, Scott A.; Gregory, Kenton.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / George S. Abela. Vol. 2130 1994. p. 82-88.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jacques, S, Buckley, LA, Prahl, SA & Gregory, K 1994, Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. in GS Abela (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2130, pp. 82-88, Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV, Los Angeles, CA, USA, 1/22/94.
Jacques S, Buckley LA, Prahl SA, Gregory K. Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. In Abela GS, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2130. 1994. p. 82-88
Jacques, Steven ; Buckley, Lisa A. ; Prahl, Scott A. ; Gregory, Kenton. / Quantifying psoralen in tissues by fluorescence : dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis. Proceedings of SPIE - The International Society for Optical Engineering. editor / George S. Abela. Vol. 2130 1994. pp. 82-88
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