Quantifying freezing of gait in Parkinson's disease during the instrumented timed up and go test

Research output: Chapter in Book/Report/Conference proceedingConference contribution

29 Scopus citations

Abstract

Over half of patients with PD eventually develop freezing of gait (FoG), an intermittent failure to initiate or maintain walking that is often associated with trembling of the legs. We tested 21 PD with FoG, 27 PD without FoG, and 21 healthy elderly people in a clinic with the Intrumented Timed Up and Go test (ITUG). FoG was quantified from the power spectral density of the antero-posterior shank acceleration from which a Frequency Ratio was calculated as the square of the total power in the 3-8 Hz band, divided by the square of the total power in the.5-3 Hz band. Spatiotemporal gait parameters calculated from synchronized gyroscopes on the two legs were also measured in these subjects. The Frequency Ratio was significantly larger in freezers than in non-freezers or control subjects. It better differentiated gait disorders between PD subjects with and without FoG than traditional gait measures such as stride length, stride velocity and double support time. The Frequency Ratio was validated as significantly correlated with self-perceived severity of gait and balance confidence. This Freezing Ratio will be useful to quantify FoG during a simple ITUG, a popular clinical test of mobility.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages1198-1201
Number of pages4
DOIs
StatePublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Mancini, M., Priest, K. C., Nutt, J. G., & Horak, F. B. (2012). Quantifying freezing of gait in Parkinson's disease during the instrumented timed up and go test. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 1198-1201). [6346151] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6346151