Quantifying blood flow dynamics during cardiac development

Demystifying computational methods

Katherine Courchaine, Sandra Rugonyi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Blood flow conditions (haemodynamics) are crucial for proper cardiovascular development. Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling that influence cardiovascular growth and development during embryonic stages and beyond. Altered blood flow conditions are a hallmark of congenital heart disease, and disrupted blood flow at early embryonic stages is known to lead to congenital heart malformations. In spite of this, many of the mechanisms by which blood flow mechanics affect cardiovascular development remain unknown. This is due in part to the challenges involved in quantifying blood flow dynamics and the forces exerted by blood flow on developing cardiovascular tissues. Recent technologies, however, have allowed precise measurement of blood flow parameters and cardiovascular geometry even at early embryonic stages. Combined with computational fluid dynamics techniques, it is possible to quantify haemodynamic parameters and their changes over development, which is a crucial step in the quest for understanding the role of mechanical cues on heart and vascular formation. This study summarizes some fundamental aspects of modelling blood flow dynamics, with a focus on three-dimensional modelling techniques, and discusses relevant studies that are revealing the details of blood flow and their influence on cardiovascular development. This article is part of the Theo Murphy meeting issue ‘Mechanics of development’.

Original languageEnglish (US)
Article number20170330
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume373
Issue number1759
DOIs
StatePublished - Jan 1 2018

Fingerprint

Computational methods
blood flow
Blood
methodology
Hemodynamics
hemodynamics
Mechanics
mechanics
heart
Congenital Heart Defects
heart diseases
Hydrodynamics
Growth and Development
blood vessels
Cues
Blood Vessels
Heart Diseases
Computational fluid dynamics
growth and development
fluid mechanics

Keywords

  • Blood flow dynamics
  • Cardiovascular development
  • Computational fluid dynamics
  • Haemodynamics
  • Mechanotransduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Quantifying blood flow dynamics during cardiac development : Demystifying computational methods. / Courchaine, Katherine; Rugonyi, Sandra.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 373, No. 1759, 20170330, 01.01.2018.

Research output: Contribution to journalReview article

@article{0c33fdc984c941e19958e3c8014279bc,
title = "Quantifying blood flow dynamics during cardiac development: Demystifying computational methods",
abstract = "Blood flow conditions (haemodynamics) are crucial for proper cardiovascular development. Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling that influence cardiovascular growth and development during embryonic stages and beyond. Altered blood flow conditions are a hallmark of congenital heart disease, and disrupted blood flow at early embryonic stages is known to lead to congenital heart malformations. In spite of this, many of the mechanisms by which blood flow mechanics affect cardiovascular development remain unknown. This is due in part to the challenges involved in quantifying blood flow dynamics and the forces exerted by blood flow on developing cardiovascular tissues. Recent technologies, however, have allowed precise measurement of blood flow parameters and cardiovascular geometry even at early embryonic stages. Combined with computational fluid dynamics techniques, it is possible to quantify haemodynamic parameters and their changes over development, which is a crucial step in the quest for understanding the role of mechanical cues on heart and vascular formation. This study summarizes some fundamental aspects of modelling blood flow dynamics, with a focus on three-dimensional modelling techniques, and discusses relevant studies that are revealing the details of blood flow and their influence on cardiovascular development. This article is part of the Theo Murphy meeting issue ‘Mechanics of development’.",
keywords = "Blood flow dynamics, Cardiovascular development, Computational fluid dynamics, Haemodynamics, Mechanotransduction",
author = "Katherine Courchaine and Sandra Rugonyi",
year = "2018",
month = "1",
day = "1",
doi = "10.1098/rstb.2017.0330",
language = "English (US)",
volume = "373",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "0962-8436",
publisher = "The Royal Society",
number = "1759",

}

TY - JOUR

T1 - Quantifying blood flow dynamics during cardiac development

T2 - Demystifying computational methods

AU - Courchaine, Katherine

AU - Rugonyi, Sandra

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Blood flow conditions (haemodynamics) are crucial for proper cardiovascular development. Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling that influence cardiovascular growth and development during embryonic stages and beyond. Altered blood flow conditions are a hallmark of congenital heart disease, and disrupted blood flow at early embryonic stages is known to lead to congenital heart malformations. In spite of this, many of the mechanisms by which blood flow mechanics affect cardiovascular development remain unknown. This is due in part to the challenges involved in quantifying blood flow dynamics and the forces exerted by blood flow on developing cardiovascular tissues. Recent technologies, however, have allowed precise measurement of blood flow parameters and cardiovascular geometry even at early embryonic stages. Combined with computational fluid dynamics techniques, it is possible to quantify haemodynamic parameters and their changes over development, which is a crucial step in the quest for understanding the role of mechanical cues on heart and vascular formation. This study summarizes some fundamental aspects of modelling blood flow dynamics, with a focus on three-dimensional modelling techniques, and discusses relevant studies that are revealing the details of blood flow and their influence on cardiovascular development. This article is part of the Theo Murphy meeting issue ‘Mechanics of development’.

AB - Blood flow conditions (haemodynamics) are crucial for proper cardiovascular development. Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling that influence cardiovascular growth and development during embryonic stages and beyond. Altered blood flow conditions are a hallmark of congenital heart disease, and disrupted blood flow at early embryonic stages is known to lead to congenital heart malformations. In spite of this, many of the mechanisms by which blood flow mechanics affect cardiovascular development remain unknown. This is due in part to the challenges involved in quantifying blood flow dynamics and the forces exerted by blood flow on developing cardiovascular tissues. Recent technologies, however, have allowed precise measurement of blood flow parameters and cardiovascular geometry even at early embryonic stages. Combined with computational fluid dynamics techniques, it is possible to quantify haemodynamic parameters and their changes over development, which is a crucial step in the quest for understanding the role of mechanical cues on heart and vascular formation. This study summarizes some fundamental aspects of modelling blood flow dynamics, with a focus on three-dimensional modelling techniques, and discusses relevant studies that are revealing the details of blood flow and their influence on cardiovascular development. This article is part of the Theo Murphy meeting issue ‘Mechanics of development’.

KW - Blood flow dynamics

KW - Cardiovascular development

KW - Computational fluid dynamics

KW - Haemodynamics

KW - Mechanotransduction

UR - http://www.scopus.com/inward/record.url?scp=85054141283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054141283&partnerID=8YFLogxK

U2 - 10.1098/rstb.2017.0330

DO - 10.1098/rstb.2017.0330

M3 - Review article

VL - 373

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0962-8436

IS - 1759

M1 - 20170330

ER -