Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

Aiping Liu, Andrew Nickerson, Aaron Troyer, Xin Yin, Robert Cary, Kent Thornburg, Ruikang Wang, Sandra Rugonyi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.

Original languageEnglish (US)
Pages (from-to)855-867
Number of pages13
JournalComputers and Structures
Volume89
Issue number11-12
DOIs
StatePublished - Jun 2011

Fingerprint

Wall Shear Stress
Blood Flow
Cardiac
Shear stress
Blood
Morphogenesis
Finite Element Modeling
Hemodynamics
Embryo
Flow Field
Flow fields
Imaging
Tissue
Distinct
Imaging techniques
Methodology
Heart

Keywords

  • Cardiac outflow tract
  • Chick embryonic heart
  • Computational fluid dynamics
  • Wall shear stress

ASJC Scopus subject areas

  • Computer Science Applications
  • Civil and Structural Engineering
  • Mechanical Engineering
  • Modeling and Simulation
  • Materials Science(all)

Cite this

Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts. / Liu, Aiping; Nickerson, Andrew; Troyer, Aaron; Yin, Xin; Cary, Robert; Thornburg, Kent; Wang, Ruikang; Rugonyi, Sandra.

In: Computers and Structures, Vol. 89, No. 11-12, 06.2011, p. 855-867.

Research output: Contribution to journalArticle

Liu, Aiping ; Nickerson, Andrew ; Troyer, Aaron ; Yin, Xin ; Cary, Robert ; Thornburg, Kent ; Wang, Ruikang ; Rugonyi, Sandra. / Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts. In: Computers and Structures. 2011 ; Vol. 89, No. 11-12. pp. 855-867.
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AU - Wang, Ruikang

AU - Rugonyi, Sandra

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