Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

Aiping Liu, Andrew Nickerson, Aaron Troyer, Xin Yin, Robert Cary, Kent Thornburg, Ruikang Wang, Sandra Rugonyi

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.

Original languageEnglish (US)
Pages (from-to)855-867
Number of pages13
JournalComputers and Structures
Volume89
Issue number11-12
DOIs
StatePublished - Jun 1 2011

Keywords

  • Cardiac outflow tract
  • Chick embryonic heart
  • Computational fluid dynamics
  • Wall shear stress

ASJC Scopus subject areas

  • Civil and Structural Engineering
  • Modeling and Simulation
  • Materials Science(all)
  • Mechanical Engineering
  • Computer Science Applications

Fingerprint Dive into the research topics of 'Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts'. Together they form a unique fingerprint.

  • Cite this