Quantification of myocardial perfusion with contrast echocardiography during venous injection of contrast

S. Firoozan, Kevin Wei, G. Ates, N. Goodman, D. Skyba, Sanjiv Kaul

Research output: Contribution to journalArticle

Abstract

Quantification of changes in myocardial blood flow (MBF) and myocardial blood volume (MBV) with myocardial contrast echocardiography (MCE) depends critically upon identifying the linear portion of the relationship between microbubble concentration and measured videointensity. MBV and MBF are closely coupled during infusion of inotropes and with normal coronary arteries any increase in epicardial flow results in an increase in MBF. Increasing amounts of a contrast agent MRX-115 (12.5-300μl) was injected intravenously (IV) at baseline and during IV infusion of increasing amounts of adrenaline in 6 dogs with a flow probe around the left anterior descending (LAD) coronary artery. Intermittent harmonic MCE was performed gated to end-systole and peak video intensity measured over the LAD bed. Microbubble dose was plotted against peak background subtracted videointensity at baseline and during hyperaemia. From the linear ranges of these plotts a dose of 0.1 ml of contrast was selected for injection and kept constant for the remainder of the experiment. An excellent correlation was found between the peak myocardial background-subtracted video intensities in the LAD bed and the LAD flow rate (r=0.9, n=23 P

Original languageEnglish (US)
JournalHeart
Volume77
Issue numberSUPPL. 1
StatePublished - May 1997
Externally publishedYes

Fingerprint

Echocardiography
Microbubbles
perflutren
Perfusion
Blood Volume
Injections
Coronary Vessels
Systole
Hyperemia
Contrast Media
Epinephrine
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Quantification of myocardial perfusion with contrast echocardiography during venous injection of contrast. / Firoozan, S.; Wei, Kevin; Ates, G.; Goodman, N.; Skyba, D.; Kaul, Sanjiv.

In: Heart, Vol. 77, No. SUPPL. 1, 05.1997.

Research output: Contribution to journalArticle

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AU - Wei, Kevin

AU - Ates, G.

AU - Goodman, N.

AU - Skyba, D.

AU - Kaul, Sanjiv

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