Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle

Cecily Bishop, Theodore A. Molskness, Fuhua Xu, J. Todd Belcik, Jonathan Lindner, Ov Slayden, Richard Stouffer

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Background: The objective of the current study was to determine changes to vascular parameters of nonhuman primate dominant ovarian structures by dynamic contrast-enhanced ultrasound (DCE-US). Materials and Methods: Dynamic contrast-enhanced ultrasound with intravenous microbubble infusion was performed on the rhesus macaque ovary bearing the pre-ovulatory follicle and corpus luteum (CL) sequentially during the natural luteal phase (n = 8) and GnRH antagonist (antide)-induced luteal regression (n = 6). Results: Changes in luteal blood volume (BV) and vascular flow (VF) were observed between stages of the luteal phase Luteal BV was highest in early stage CL, before decreasing 2.5-fold in late stage CL (P <0.06); in contrast, luteal VF peaked at mid luteal stage (P <0.01). Two females identified with luteal insufficiency trended toward lower peak BV, compared to typical CLs. Another female was identified with a luteal cyst on the contralateral ovary, and a CL that regressed before P levels declined. After 72 hours of antide exposure, BV was reduced 2.3-fold (P = 0.03). Conclusions: DCE-US provides a sensitive, non-invasive measurement of the dynamics of blood volume and flow in dominant ovarian structures.

    Original languageEnglish (US)
    Pages (from-to)445-454
    Number of pages10
    JournalJournal of Medical Primatology
    Volume43
    Issue number6
    DOIs
    StatePublished - Dec 1 2014

    Fingerprint

    menstrual cycle
    blood volume
    Corpus Luteum
    Menstrual Cycle
    Blood Volume
    corpus luteum
    blood vessels
    Primates
    Blood Vessels
    Luteal Phase
    Ovary
    Luteolysis
    Microbubbles
    Ovarian Cysts
    microbubbles
    Macaca mulatta
    Intravenous Infusions
    Gonadotropin-Releasing Hormone
    ovarian cysts
    blood flow

    Keywords

    • Dynamic contrast-enhanced ultrasound
    • Luteal blood flow
    • Non-human primate
    • Ovarian vasculature
    • Rhesus monkey

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)
    • Medicine(all)

    Cite this

    Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle. / Bishop, Cecily; Molskness, Theodore A.; Xu, Fuhua; Belcik, J. Todd; Lindner, Jonathan; Slayden, Ov; Stouffer, Richard.

    In: Journal of Medical Primatology, Vol. 43, No. 6, 01.12.2014, p. 445-454.

    Research output: Contribution to journalArticle

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    AU - Lindner, Jonathan

    AU - Slayden, Ov

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