Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease

Craig Broberg, Sumeet S. Chugh, Catherine Conklin, David Sahn, Michael Jerosch-Herold

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

Background - The etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI. Methods and Results-Patients with ACHD (n=50) were studied with cardiac MRI to quantify systemic ventricular volume and function and diffuse fibrosis. The fibrosis index for a single midventricular plane of the systemic ventricle was quantified by measuring T1 values for blood pool and myocardium before and after administration of gadolinium (0.15 mmol/kg) and then adjusted for hematocrit. Results were compared to healthy volunteers (normal controls, n=14) and patients with acquired heart failure (positive controls, n=4). Patients studied (age, 37±12 years; female sex, 40%) included 11 with a systemic right ventricle (RV), 17 with tetralogy of Fallot, 10 with cyanosis, and 12 with other lesions. The fibrosis index was significantly elevated in patients with ACHD compared to normal controls (31.9±4.9% versus 24.8±2.0%; P=0.001). Values were highest in patients with a systemic RV (35.0±5.8%; P

Original languageEnglish (US)
Pages (from-to)727-734
Number of pages8
JournalCirculation: Cardiovascular Imaging
Volume3
Issue number6
DOIs
StatePublished - Nov 2010

Fingerprint

Heart Diseases
Fibrosis
Heart Ventricles
Ventricular Dysfunction
Cyanosis
Tetralogy of Fallot
Ventricular Function
Gadolinium
Hematocrit
Myocardium
Healthy Volunteers
Heart Failure

Keywords

  • Cyanosis
  • Endomyocardial fibrosis
  • Gadolinium
  • Heart defects, congenital
  • Heart failure
  • Ventricular dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease. / Broberg, Craig; Chugh, Sumeet S.; Conklin, Catherine; Sahn, David; Jerosch-Herold, Michael.

In: Circulation: Cardiovascular Imaging, Vol. 3, No. 6, 11.2010, p. 727-734.

Research output: Contribution to journalArticle

Broberg, Craig ; Chugh, Sumeet S. ; Conklin, Catherine ; Sahn, David ; Jerosch-Herold, Michael. / Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease. In: Circulation: Cardiovascular Imaging. 2010 ; Vol. 3, No. 6. pp. 727-734.
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