Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound

Se Joong Rim, Howard Leong-Poi, Jonathan Lindner, Daniel Couture, Dilantha Ellegala, Holland Mason, Marcel Durieux, Neal F. Kassel, Sanjiv Kaul

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Background - No noninvasive technique is currently capable of "real-time" assessment and monitoring of cerebral blood flow (CBF). We hypothesized that cerebral perfusion could be accurately measured and monitored in "real time" with contrast-enhanced ultrasound (CEU). Methods and Results - Cerebral perfusion was assessed in 9 dogs through a craniotomy with CEU at baseline and during hypercapnia and hypocapnia while normoxia was maintained. Cerebral microvascular blood volume (A), microbubble velocity (β), and blood flow (A×β) were calculated from time-versus-acoustic intensity relations. Compared with baseline, hypercapnia and hypocapnia significantly increased and decreased CBF, respectively, as measured by CEU. These changes in blood flow were mediated by changes in both A and β. A good correlation was found between A×β derived from CEU and CBF measured by radiolabeled microspheres (y=0.67x-0.04, r=0.91, P

Original languageEnglish (US)
Pages (from-to)2582-2587
Number of pages6
JournalCirculation
Volume104
Issue number21
StatePublished - Nov 20 2001
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Hypocapnia
Hypercapnia
Perfusion
Microbubbles
Blood Flow Velocity
Craniotomy
Microspheres
Acoustics
Dogs

Keywords

  • Cerebrovascular circulation
  • Contrast media
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Rim, S. J., Leong-Poi, H., Lindner, J., Couture, D., Ellegala, D., Mason, H., ... Kaul, S. (2001). Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound. Circulation, 104(21), 2582-2587.

Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound. / Rim, Se Joong; Leong-Poi, Howard; Lindner, Jonathan; Couture, Daniel; Ellegala, Dilantha; Mason, Holland; Durieux, Marcel; Kassel, Neal F.; Kaul, Sanjiv.

In: Circulation, Vol. 104, No. 21, 20.11.2001, p. 2582-2587.

Research output: Contribution to journalArticle

Rim, SJ, Leong-Poi, H, Lindner, J, Couture, D, Ellegala, D, Mason, H, Durieux, M, Kassel, NF & Kaul, S 2001, 'Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound', Circulation, vol. 104, no. 21, pp. 2582-2587.
Rim SJ, Leong-Poi H, Lindner J, Couture D, Ellegala D, Mason H et al. Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound. Circulation. 2001 Nov 20;104(21):2582-2587.
Rim, Se Joong ; Leong-Poi, Howard ; Lindner, Jonathan ; Couture, Daniel ; Ellegala, Dilantha ; Mason, Holland ; Durieux, Marcel ; Kassel, Neal F. ; Kaul, Sanjiv. / Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound. In: Circulation. 2001 ; Vol. 104, No. 21. pp. 2582-2587.
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AU - Leong-Poi, Howard

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AU - Couture, Daniel

AU - Ellegala, Dilantha

AU - Mason, Holland

AU - Durieux, Marcel

AU - Kassel, Neal F.

AU - Kaul, Sanjiv

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