Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography

Sang Won Lee, Andrew E. Heidari, David Yoon, David Mukai, Tirunelveli Ramalingam, Sari Mahon, Jiechen Yin, Joseph Jing, Gangjun Liu, Zhongping Chen, Matthew Brenner

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Smoke inhalation injury is frequently accompanied by cyanide poisoning that may result in substantial morbidity and mortality, and methods are needed to quantitatively determine extent of airway injury. We utilized a 3-D endoscopic frequency-domain optical coherence tomography (FD-OCT) constructed with a swept-source laser to investigate morphological airway changes following smoke and cyanide exposure in rabbits. The thickness of the mucosal area between the epithelium and cartilage in the airway was measured and quantified. 3-D endoscopic FD-OCT was able to detect significant increases in the thickness of the tracheal walls of the rabbit beginning almost immediately after smoke inhalation injuries which were similar to those with combined smoke and cyanide poisoning.

Original languageEnglish (US)
Pages (from-to)243-254
Number of pages12
JournalBiomedical Optics Express
Volume2
Issue number2
DOIs
StatePublished - Feb 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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    Lee, S. W., Heidari, A. E., Yoon, D., Mukai, D., Ramalingam, T., Mahon, S., Yin, J., Jing, J., Liu, G., Chen, Z., & Brenner, M. (2011). Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography. Biomedical Optics Express, 2(2), 243-254. https://doi.org/10.1364/BOE.2.000243