Quadruple wild-type (WT) GIST: Defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways

Maria A. Pantaleo, Margherita Nannini, Christopher L. Corless, Michael C. Heinrich

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

A subset of GISTs lack mutations in the KIT/PDGFRA or RAS pathways and yet retain an intact succinate dehydrogensase (SDH) complex. We propose that these KIT/PDGFRA/SDH/RAS-P WT GIST tumors be designated as quadruple wild-type (WT) GIST. Further molecular and clinicophatological characterization of quadruple WT GIST will help to determine their prognosis as well as assist in the optimization of medical management, including clinical test of novel therapies.

Original languageEnglish (US)
Pages (from-to)101-103
Number of pages3
JournalCancer medicine
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • BRAF
  • GIST
  • Gastrointestinal stromal tumors
  • NF-1
  • Quadruple WT
  • Quadruple negative
  • RAS
  • SDH deficiency
  • SDHA
  • SDHB
  • Wild type

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Quadruple wild-type (WT) GIST: Defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways'. Together they form a unique fingerprint.

  • Cite this