Quadruple wild-type (WT) GIST: Defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways

Maria A. Pantaleo, Margherita Nannini, Christopher Corless, Michael Heinrich

Research output: Contribution to journalArticle

50 Scopus citations


A subset of GISTs lack mutations in the KIT/PDGFRA or RAS pathways and yet retain an intact succinate dehydrogensase (SDH) complex. We propose that these KIT/PDGFRA/SDH/RAS-P WT GIST tumors be designated as quadruple wild-type (WT) GIST. Further molecular and clinicophatological characterization of quadruple WT GIST will help to determine their prognosis as well as assist in the optimization of medical management, including clinical test of novel therapies.

Original languageEnglish (US)
Pages (from-to)101-103
Number of pages3
JournalCancer Medicine
Issue number1
StatePublished - Jan 1 2015



  • BRAF
  • Gastrointestinal stromal tumors
  • GIST
  • NF-1
  • Quadruple negative
  • Quadruple WT
  • RAS
  • SDH deficiency
  • SDHA
  • SDHB
  • Wild type

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this