TY - JOUR
T1 - Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP
AU - King, S. C.
AU - Fleming, S. R.
AU - Brechtel, C.
PY - 1995
Y1 - 1995
N2 - Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.
AB - Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.
UR - http://www.scopus.com/inward/record.url?scp=0029149550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029149550&partnerID=8YFLogxK
U2 - 10.1128/jb.177.18.5381-5382.1995
DO - 10.1128/jb.177.18.5381-5382.1995
M3 - Article
C2 - 7665533
AN - SCOPUS:0029149550
SN - 0021-9193
VL - 177
SP - 5381
EP - 5382
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 18
ER -