Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP

S. C. King, S. R. Fleming, C. Brechtel

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.

Original languageEnglish (US)
Pages (from-to)5381-5382
Number of pages2
JournalJournal of bacteriology
Volume177
Issue number18
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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