Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP

Steven King, S. R. Fleming, C. Brechtel

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.

Original languageEnglish (US)
Pages (from-to)5381-5382
Number of pages2
JournalJournal of Bacteriology
Volume177
Issue number18
StatePublished - 1995
Externally publishedYes

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Aminobutyrates
Membrane Transport Proteins
Carboxylic Acids
Escherichia coli
pyridine

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP. / King, Steven; Fleming, S. R.; Brechtel, C.

In: Journal of Bacteriology, Vol. 177, No. 18, 1995, p. 5381-5382.

Research output: Contribution to journalArticle

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