TY - JOUR
T1 - Pyoderma Gangrenosum
T2 - What Do We Know Now?
AU - McKenzie, Fatima
AU - Arthur, Megan
AU - Ortega-Loayza, Alex G.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Purpose of Review: To summarize the recent literature on the pathophysiology, diagnosis, and treatment of pyoderma gangrenosum. Recent Findings: A complex interplay between both the innate and adaptive immune systems underlies the pathogenesis of pyoderma gangrenosum (PG). Diagnosis remains a challenge, as there is no gold standard test to confirm the presence of the disease. Efforts to establish diagnostic criteria based on clinical findings have recently been proposed. Definitive management strategies are also lacking; however, current trends in treatment have favored the use of immunosuppressive medications, wound care management, and analgesia. Summary: PG is a complex disease that continues to pose a challenge. Current research on PG is focused on improving our understanding of the pathophysiology so that we might improve our diagnostic consistency and identify treatment approaches optimized for each individual patient’s specific pathology.
AB - Purpose of Review: To summarize the recent literature on the pathophysiology, diagnosis, and treatment of pyoderma gangrenosum. Recent Findings: A complex interplay between both the innate and adaptive immune systems underlies the pathogenesis of pyoderma gangrenosum (PG). Diagnosis remains a challenge, as there is no gold standard test to confirm the presence of the disease. Efforts to establish diagnostic criteria based on clinical findings have recently been proposed. Definitive management strategies are also lacking; however, current trends in treatment have favored the use of immunosuppressive medications, wound care management, and analgesia. Summary: PG is a complex disease that continues to pose a challenge. Current research on PG is focused on improving our understanding of the pathophysiology so that we might improve our diagnostic consistency and identify treatment approaches optimized for each individual patient’s specific pathology.
KW - Neutrophilic dermatosis
KW - Pyoderma gangrenosum
KW - Wounds
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U2 - 10.1007/s13671-018-0224-y
DO - 10.1007/s13671-018-0224-y
M3 - Review article
AN - SCOPUS:85069328858
SN - 2162-4933
VL - 7
SP - 147
EP - 157
JO - Current Dermatology Reports
JF - Current Dermatology Reports
IS - 3
ER -