Putting the pieces together: Necrolytic migratory erythema and the glucagonoma syndrome

Stephanie A.C. Halvorson, Erin Gilbert, Robert Hopkins, Helen Liu, Charles Lopez, Michael Chu, Marie Martin, Brett Sheppard

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Glucagonomas are slow-growing, rare pancreatic neuroendocrine tumors. They may present with paraneoplastic phenomena known together as the "glucagonoma syndrome." A hallmark sign of this syndrome is a rash known as necrolytic migratory erythema (NME). In this paper, the authors describe a patient with NME and other features of the glucagonoma syndrome. The diagnosis of this rare tumor requires an elevated serum glucagon level and imaging confirming a pancreatic tumor. Surgical and medical treatment options are reviewed. When detected early, a glucagonoma is surgically curable. It is therefore imperative that clinicians recognize the glucagonoma syndrome in order to make an accurate diagnosis and refer for treatment.

Original languageEnglish (US)
Pages (from-to)1525-1529
Number of pages5
JournalJournal of general internal medicine
Issue number11
StatePublished - Nov 2013


  • glucagonoma
  • necrolytic migratory erythema
  • neuroendocrine tumors

ASJC Scopus subject areas

  • Internal Medicine


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