Pulsatile prolactin secretion in hyperprolactinemia due to presumed pituitary stalk interruption

Mary Samuels, P. Henry, B. Kleinschmidt-Demasters, K. Lillehei, E. C. Ridgway

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

PRL, like other anterior pituitary hormones, is normally secreted in a pulsatile fashion. However, it is not known whether such pulses depend on dopamine and/or other hypothalamic factors. This question can be addressed by investigating patients with large pituitary mass lesions, since such patients often have hyperprolactinemia due to disruption of normal hypothalamic input to the pituitary gland. Six such patients (5 with non-PRL-secreting tumors and 1 with a craniopharyngioma) and 11 healthy control subjects had PRL levels measured every 15 min over 24 h. PRL pulses were located by cluster analysis. All patients had PRL pulses of normal frequency, but increased amplitude. Circadian variation in PRL pulse amplitude, present in healthy women, was abolished in tumor patients. These results imply that normal pituitary levels of dopamine do not control the generation of PRL pulses. Instead, PRL pulses may arise from the pituitary gland, with pulse amplitude and circadian rhythm modulation by dopamine and other hypothalamic factors. Alternatively, the mild hyperprolactinemia associated with large hypothalamic-pituitary tumors may represent partial impairment of dopamine secretion, with sufficient pituitary dopamine levels to maintain normal PRL pulse frequency.

Original languageEnglish (US)
Pages (from-to)1289-1293
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume73
Issue number6
StatePublished - Dec 1991
Externally publishedYes

Fingerprint

Hyperprolactinemia
Pituitary Gland
Prolactin
Dopamine
Tumors
Hypothalamic Neoplasms
Anterior Pituitary Hormones
Craniopharyngioma
Cluster analysis
Pituitary Neoplasms
Circadian Rhythm
Cluster Analysis
Neoplasms
Healthy Volunteers
Modulation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Pulsatile prolactin secretion in hyperprolactinemia due to presumed pituitary stalk interruption. / Samuels, Mary; Henry, P.; Kleinschmidt-Demasters, B.; Lillehei, K.; Ridgway, E. C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 73, No. 6, 12.1991, p. 1289-1293.

Research output: Contribution to journalArticle

Samuels, M, Henry, P, Kleinschmidt-Demasters, B, Lillehei, K & Ridgway, EC 1991, 'Pulsatile prolactin secretion in hyperprolactinemia due to presumed pituitary stalk interruption', Journal of Clinical Endocrinology and Metabolism, vol. 73, no. 6, pp. 1289-1293.
Samuels, Mary ; Henry, P. ; Kleinschmidt-Demasters, B. ; Lillehei, K. ; Ridgway, E. C. / Pulsatile prolactin secretion in hyperprolactinemia due to presumed pituitary stalk interruption. In: Journal of Clinical Endocrinology and Metabolism. 1991 ; Vol. 73, No. 6. pp. 1289-1293.
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