Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery

Aldo E. Calogero, Jeffrey A. Norton, Brett Sheppard, Samuel J. Listwak, Douglas T. Cromack, Russell Wall, Robert T. Jensen, George P. Chrousos

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To examine the response of the hypothalamic-pituitary-adrenal (HPA) axis to severe surgical stress, we measured the immunoreactive plasma levels of corticotropin-releasing hormone (CRH), corticotropin, cortisol, arginine-vasopressin (AVP), atrial natriuretic factor (ANF), neuropeptide Y (NPY), interleukin-1 (IL-1), IL-6, interferon gamma (INF), and tumor necrosis factor-alpha (TNF-α) in eight patients with Zollinger-Ellison syndrome (ZES) or mediastinal parathyroid carcinoma, all undergoing major surgery with a standardized anesthetic technique. Blood samples were drawn the morning before surgery, every 10 to 30 minutes throughout surgery (average, 308.7 ± 15 minutes), and every morning for the next 4 postoperative days (POD). During surgery, plasma CRH concentrations were slightly but not significantly elevated compared with those before surgery and with those of the next 4 POD. However, the values were within the normal range (

Original languageEnglish (US)
Pages (from-to)839-845
Number of pages7
JournalMetabolism
Volume41
Issue number8
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Zollinger-Ellison Syndrome
Parathyroid Neoplasms
Arginine Vasopressin
Neuropeptide Y
Atrial Natriuretic Factor
Interleukin-1
Adrenocorticotropic Hormone
Interferon-gamma
Anesthetics
Hydrocortisone
Interleukin-6
Reference Values
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Calogero, A. E., Norton, J. A., Sheppard, B., Listwak, S. J., Cromack, D. T., Wall, R., ... Chrousos, G. P. (1992). Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery. Metabolism, 41(8), 839-845. https://doi.org/10.1016/0026-0495(92)90164-6

Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery. / Calogero, Aldo E.; Norton, Jeffrey A.; Sheppard, Brett; Listwak, Samuel J.; Cromack, Douglas T.; Wall, Russell; Jensen, Robert T.; Chrousos, George P.

In: Metabolism, Vol. 41, No. 8, 1992, p. 839-845.

Research output: Contribution to journalArticle

Calogero, AE, Norton, JA, Sheppard, B, Listwak, SJ, Cromack, DT, Wall, R, Jensen, RT & Chrousos, GP 1992, 'Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery', Metabolism, vol. 41, no. 8, pp. 839-845. https://doi.org/10.1016/0026-0495(92)90164-6
Calogero, Aldo E. ; Norton, Jeffrey A. ; Sheppard, Brett ; Listwak, Samuel J. ; Cromack, Douglas T. ; Wall, Russell ; Jensen, Robert T. ; Chrousos, George P. / Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery. In: Metabolism. 1992 ; Vol. 41, No. 8. pp. 839-845.
@article{f68a499bf6fe4379bcbf06054f731692,
title = "Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery",
abstract = "To examine the response of the hypothalamic-pituitary-adrenal (HPA) axis to severe surgical stress, we measured the immunoreactive plasma levels of corticotropin-releasing hormone (CRH), corticotropin, cortisol, arginine-vasopressin (AVP), atrial natriuretic factor (ANF), neuropeptide Y (NPY), interleukin-1 (IL-1), IL-6, interferon gamma (INF), and tumor necrosis factor-alpha (TNF-α) in eight patients with Zollinger-Ellison syndrome (ZES) or mediastinal parathyroid carcinoma, all undergoing major surgery with a standardized anesthetic technique. Blood samples were drawn the morning before surgery, every 10 to 30 minutes throughout surgery (average, 308.7 ± 15 minutes), and every morning for the next 4 postoperative days (POD). During surgery, plasma CRH concentrations were slightly but not significantly elevated compared with those before surgery and with those of the next 4 POD. However, the values were within the normal range (",
author = "Calogero, {Aldo E.} and Norton, {Jeffrey A.} and Brett Sheppard and Listwak, {Samuel J.} and Cromack, {Douglas T.} and Russell Wall and Jensen, {Robert T.} and Chrousos, {George P.}",
year = "1992",
doi = "10.1016/0026-0495(92)90164-6",
language = "English (US)",
volume = "41",
pages = "839--845",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "8",

}

TY - JOUR

T1 - Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery

AU - Calogero, Aldo E.

AU - Norton, Jeffrey A.

AU - Sheppard, Brett

AU - Listwak, Samuel J.

AU - Cromack, Douglas T.

AU - Wall, Russell

AU - Jensen, Robert T.

AU - Chrousos, George P.

PY - 1992

Y1 - 1992

N2 - To examine the response of the hypothalamic-pituitary-adrenal (HPA) axis to severe surgical stress, we measured the immunoreactive plasma levels of corticotropin-releasing hormone (CRH), corticotropin, cortisol, arginine-vasopressin (AVP), atrial natriuretic factor (ANF), neuropeptide Y (NPY), interleukin-1 (IL-1), IL-6, interferon gamma (INF), and tumor necrosis factor-alpha (TNF-α) in eight patients with Zollinger-Ellison syndrome (ZES) or mediastinal parathyroid carcinoma, all undergoing major surgery with a standardized anesthetic technique. Blood samples were drawn the morning before surgery, every 10 to 30 minutes throughout surgery (average, 308.7 ± 15 minutes), and every morning for the next 4 postoperative days (POD). During surgery, plasma CRH concentrations were slightly but not significantly elevated compared with those before surgery and with those of the next 4 POD. However, the values were within the normal range (

AB - To examine the response of the hypothalamic-pituitary-adrenal (HPA) axis to severe surgical stress, we measured the immunoreactive plasma levels of corticotropin-releasing hormone (CRH), corticotropin, cortisol, arginine-vasopressin (AVP), atrial natriuretic factor (ANF), neuropeptide Y (NPY), interleukin-1 (IL-1), IL-6, interferon gamma (INF), and tumor necrosis factor-alpha (TNF-α) in eight patients with Zollinger-Ellison syndrome (ZES) or mediastinal parathyroid carcinoma, all undergoing major surgery with a standardized anesthetic technique. Blood samples were drawn the morning before surgery, every 10 to 30 minutes throughout surgery (average, 308.7 ± 15 minutes), and every morning for the next 4 postoperative days (POD). During surgery, plasma CRH concentrations were slightly but not significantly elevated compared with those before surgery and with those of the next 4 POD. However, the values were within the normal range (

UR - http://www.scopus.com/inward/record.url?scp=0026755621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026755621&partnerID=8YFLogxK

U2 - 10.1016/0026-0495(92)90164-6

DO - 10.1016/0026-0495(92)90164-6

M3 - Article

VL - 41

SP - 839

EP - 845

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 8

ER -