TY - JOUR
T1 - Pulmonary surfactant
T2 - Phase behavior and function
AU - Piknova, Barbora
AU - Schram, Vincent
AU - Hall, Stephen B.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Pulmonary surfactant functions by first flowing rapidly into the alveolar air/water interface, but then resisting collapse from the surface when the adsorbed interfacial film is compressed during exhalation. Widely accepted models emphasize the importance of phase behavior in both processes. Recent studies show, however, that fluidity is a relatively minor determinant of adsorption and that solid films, which resist collapse, can form by kinetic processes unrelated to equilibrium phase behavior.
AB - Pulmonary surfactant functions by first flowing rapidly into the alveolar air/water interface, but then resisting collapse from the surface when the adsorbed interfacial film is compressed during exhalation. Widely accepted models emphasize the importance of phase behavior in both processes. Recent studies show, however, that fluidity is a relatively minor determinant of adsorption and that solid films, which resist collapse, can form by kinetic processes unrelated to equilibrium phase behavior.
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U2 - 10.1016/S0959-440X(02)00352-4
DO - 10.1016/S0959-440X(02)00352-4
M3 - Review article
C2 - 12163072
AN - SCOPUS:0036667738
SN - 0959-440X
VL - 12
SP - 487
EP - 494
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 4
ER -