Pulmonary surfactant

Phase behavior and function

Barbora Piknova, Vincent Schram, Stephen (Steve) Hall

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Pulmonary surfactant functions by first flowing rapidly into the alveolar air/water interface, but then resisting collapse from the surface when the adsorbed interfacial film is compressed during exhalation. Widely accepted models emphasize the importance of phase behavior in both processes. Recent studies show, however, that fluidity is a relatively minor determinant of adsorption and that solid films, which resist collapse, can form by kinetic processes unrelated to equilibrium phase behavior.

Original languageEnglish (US)
Pages (from-to)487-494
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume12
Issue number4
DOIs
StatePublished - Aug 1 2002

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Exhalation
Pulmonary Surfactants
Adsorption
Air
Water

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Pulmonary surfactant : Phase behavior and function. / Piknova, Barbora; Schram, Vincent; Hall, Stephen (Steve).

In: Current Opinion in Structural Biology, Vol. 12, No. 4, 01.08.2002, p. 487-494.

Research output: Contribution to journalArticle

Piknova, Barbora ; Schram, Vincent ; Hall, Stephen (Steve). / Pulmonary surfactant : Phase behavior and function. In: Current Opinion in Structural Biology. 2002 ; Vol. 12, No. 4. pp. 487-494.
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