Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: An emerging public health disease

Kevin Winthrop, Erin McNelley, Brian Kendall, Allison Marshall-Olson, Christy Morris, Maureen Cassidy, Ashlen Saulson, Katrina Hedberg

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

Rationale: Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown. Objectives: To determine the disease prevalence, clinical features, and risk factors for NTM disease, and to examine the predictive value of the microbiologic criteria of the American Thoracic Society (ATS)/Infectious Diseases Society of America (IDSA) pulmonary NTM case definition for true NTM disease. Methods: We identified all Oregon residents during 2005-2006 with at least one respiratory mycobacterial isolate. From a population-based subset of these patients, we collected clinical and radiologic information and used the ATS/IDSA pulmonary NTM disease criteria to define disease. Measurements and Main Results: In the 2-year time period, 807 Oregonians hadone or more respiratory NTM isolates. Four hundred and seven (50%) resided within the Portland metropolitan region, among which 283 (70%) had evaluable clinical records. For those with records, 134 (47%) met ATS/IDSA pulmonary NTM disease criteria for a minimum overall 2-year period prevalence of 8.6/100,000 persons, and 20.4/100,000 in those at least 50 years of age within the Portland region. Case subjects were 66 years of age (median; range, 12-92 yr), frequently female (59%), and most with disease caused by Mycobacterium avium complex (88%). Cavitation (24.5%), bronchiectasis (16%), chronic obstructive pulmonary disease (28%), and immunosuppressive therapy (25.5%)were common. Eighty-six percent of patients meeting the ATS/IDSA microbiologic criteria for disease alsomet the full ATS/IDSA disease criteria. Conclusions: Respiratory NTM isolates frequently represent disease. Pulmonary NTM disease is not uncommon, particularly among elderly females. The ATS/IDSA microbiologic criteria are highly predictive of disease and could be useful for laboratory-based NTM disease surveillance.

Original languageEnglish (US)
Pages (from-to)977-982
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume182
Issue number7
DOIs
StatePublished - Oct 1 2010

Fingerprint

Nontuberculous Mycobacteria
Public Health
Lung
Communicable Diseases
Thorax
Mycobacterium avium Complex
Bronchiectasis
Immunosuppressive Agents
Chronic Obstructive Pulmonary Disease
Lung Diseases

Keywords

  • Bronchiectasis
  • Disease prevalence
  • Epidemiology
  • Nontuberculous mycobacteria
  • Pulmonary disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Pulmonary nontuberculous mycobacterial disease prevalence and clinical features : An emerging public health disease. / Winthrop, Kevin; McNelley, Erin; Kendall, Brian; Marshall-Olson, Allison; Morris, Christy; Cassidy, Maureen; Saulson, Ashlen; Hedberg, Katrina.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 182, No. 7, 01.10.2010, p. 977-982.

Research output: Contribution to journalArticle

Winthrop, Kevin ; McNelley, Erin ; Kendall, Brian ; Marshall-Olson, Allison ; Morris, Christy ; Cassidy, Maureen ; Saulson, Ashlen ; Hedberg, Katrina. / Pulmonary nontuberculous mycobacterial disease prevalence and clinical features : An emerging public health disease. In: American Journal of Respiratory and Critical Care Medicine. 2010 ; Vol. 182, No. 7. pp. 977-982.
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abstract = "Rationale: Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown. Objectives: To determine the disease prevalence, clinical features, and risk factors for NTM disease, and to examine the predictive value of the microbiologic criteria of the American Thoracic Society (ATS)/Infectious Diseases Society of America (IDSA) pulmonary NTM case definition for true NTM disease. Methods: We identified all Oregon residents during 2005-2006 with at least one respiratory mycobacterial isolate. From a population-based subset of these patients, we collected clinical and radiologic information and used the ATS/IDSA pulmonary NTM disease criteria to define disease. Measurements and Main Results: In the 2-year time period, 807 Oregonians hadone or more respiratory NTM isolates. Four hundred and seven (50{\%}) resided within the Portland metropolitan region, among which 283 (70{\%}) had evaluable clinical records. For those with records, 134 (47{\%}) met ATS/IDSA pulmonary NTM disease criteria for a minimum overall 2-year period prevalence of 8.6/100,000 persons, and 20.4/100,000 in those at least 50 years of age within the Portland region. Case subjects were 66 years of age (median; range, 12-92 yr), frequently female (59{\%}), and most with disease caused by Mycobacterium avium complex (88{\%}). Cavitation (24.5{\%}), bronchiectasis (16{\%}), chronic obstructive pulmonary disease (28{\%}), and immunosuppressive therapy (25.5{\%})were common. Eighty-six percent of patients meeting the ATS/IDSA microbiologic criteria for disease alsomet the full ATS/IDSA disease criteria. Conclusions: Respiratory NTM isolates frequently represent disease. Pulmonary NTM disease is not uncommon, particularly among elderly females. The ATS/IDSA microbiologic criteria are highly predictive of disease and could be useful for laboratory-based NTM disease surveillance.",
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AU - Saulson, Ashlen

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KW - Nontuberculous mycobacteria

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