Pulmonary function in young children with alpha1-antitrypsin deficiency. Comparison with matched control subjects

A. S. Buist, B. E. Adams, A. H. Azzam, G. J. Sexton

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In this paper we report the initial cross-sectional data from a prospective study of pulmonary function in children with moderately severe and severe α1-antitrypsin deficiency. Using a case-control design, our cases were 19 children 3 to 7 years of age with α1-antitrypsin deficiency, Pi phenotype ZZ or SZ. Control subjects were selected from healthy children participating in a study to establish reference values for functional residual capacity and maximal expiratory flow at functional residual capacity, using a 1:1 match for sex, height, age, and weight. We found no significant difference between the cases and their matched control subjects with respect to functional residual capacity and maximal expiratory flow at functional residual capacity. We conclude that through 7 years of age there is no gross impairment in overall pulmonary function in children with moderately severe and severe α1-antitrypsin deficiency, Pi phenotypes ZZ and SZ.

Original languageEnglish (US)
Pages (from-to)817-822
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume122
Issue number6
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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