Pulmonary elastin synthesis and deposition in developing and mature sheep: Effects of intrauterine growth restriction

Megan L. Cock, Belinda J. Joyce, Stuart B. Hooper, Megan J. Wallace, Robert Gagnon, Robert A. Brace, Samantha Louey, Richard Harding

    Research output: Contribution to journalArticle

    11 Scopus citations

    Abstract

    Hypoxia and nutrient restriction during gestation restrict fetal growth and alter lung development. As elastin is intimately involved in lung development, our aim was to assess pulmonary elastin synthesis and deposition following intrauterine growth restriction (IUGR) induced by umbilicoplacental embolization (UPE). Pulmonary tropoelastin expression and elastin content were examined at 128 days (5 days UPE) and 140 days (20 days UPE) of the 147- days gestation and at 8 weeks and 2.3 years after birth (both ∼27 days UPE) in sheep. UPE induced hypoxemia, hypoglycemia, and fetal growth restriction but did not affect pulmonary tropoelastin mRNA levels or elastin deposition at any age; furthermore, elastin content was unaltered apart from being lower at 140 days. The authors conclude that hypoxemia and undernutrition associated with IUGR do not affect elastin synthesis and deposition in fetal lungs; alterations in lung structure following IUGR must have other causes.

    Original languageEnglish (US)
    Pages (from-to)405-418
    Number of pages14
    JournalExperimental Lung Research
    Volume30
    Issue number5
    DOIs
    StatePublished - Jul 1 2004

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    Keywords

    • Alveolar formation
    • Intrauterine growth restriction
    • Lung development
    • Placental insufficiency
    • Tropoelastin

    ASJC Scopus subject areas

    • Molecular Biology
    • Pulmonary and Respiratory Medicine
    • Clinical Biochemistry

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