Pulmonary arterial hypertension: MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiacfunction, and ventricular remodeling

Jan Skrok, Monda L. Shehata, Stephen Mathai, Reda E. Girgis, Ari Zaiman, James Mudd, Danielle Boyce, Noah Lechtzin, João A C Lima, David A. Bluemke, Paul M. Hassoun, Jens Vogel-Claussen

Research output: Contribution to journalArticle

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Abstract

Purpose: To prospectively compare contrast material-enhanced (CE) magnetic resonance (MR) imaging-derived right-to-left ventricle pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) between patients with pulmonary arterial hypertension (PAH) and healthy volunteers and to correlate these measurements with survival markers in patients with PAH. Materials and Methods: This HIPAA-compliant study received institutional review board approval. Written informed consent was obtained from all participants. Forty-three patients (32 with PAH [29 women; median age, 55.4 years], 11 with scleroderma but not PAH [seven women; median age, 58.9 years]) underwent right-sided heart catheterization and 3-T CE cardiac MR imaging. Eighteen ageand sex-matched healthy control subjects (12 women; median age, 51.7 years) underwent only CE MR imaging. A short-axis saturation-recovery gradient-echo section was acquired in the basal third of both ventricles, and right-to-left-ventricle PTT, LV FWHM, and LV TTP were calculated. Statistical analysis included Kruskal-Wallis test, Wilcoxon rank sum test, Spearman correlation coefficient, multiple linear regression analysis, and Lin correlation coefficient analysis. Results: Patients had significantly longer PTT (median, 8.2 seconds; 25th-75th percentile, 6.9-9.9 seconds), FWHM (median, 8.2 seconds; 25th-75th percentile, 5.7-11.4 seconds), and TTP (median, 4.8 seconds; 25th-75th percentile, 3.9-6.5 seconds) than did control subjects (median, 6.4 seconds; 25th-75th percentile, 5.7-7.1 seconds; median, 5.2 seconds; 25th-75th percentile, 4.1-6.1 seconds; median, 3.2 seconds; 25th-75th percentile, 2.8-3.8 seconds, respectively; P <.01 for each) and subjects with scleroderma but not PAH (median, 6.5 seconds; 25th-75th percentile, 5.6-7.0 seconds; median, 5.0 seconds; 25th-75th percentile, 4.0-7.3 seconds; median, 3.6 seconds; 25th-75th percentile, 2.7-4.0 seconds, respectively; P <.02 for each). PTT, LV FWHM, and LV TTP correlated with pulmonary vascular resistance index (P <.01), right ventricular stroke volume index (P ≤ .01), and pulmonary artery capacitance (P ≤ .02). In multiple linear regression models, PTT, FWHM, and TTP were associated with mean pulmonary arterial pressure and cardiac index. Conclusion: CE MR-derived PTT, LV FWHM, and LV TTP are noninvasive compound markers of pulmonary hemodynamics and cardiac function in patients with PAH. Their predictive value for patient outcome warrants further investigation.

Original languageEnglish (US)
Pages (from-to)678-687
Number of pages10
JournalRadiology
Volume263
Issue number3
DOIs
StatePublished - 2012
Externally publishedYes

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Ventricular Remodeling
Pulmonary Hypertension
Biomarkers
Hemodynamics
Magnetic Resonance Imaging
Lung
Contrast Media
Linear Models
Nonparametric Statistics
Heart Ventricles
Healthy Volunteers
Health Insurance Portability and Accountability Act
Third Ventricle
Research Ethics Committees
Cardiac Catheterization
Informed Consent
Vascular Resistance
Stroke Volume
Pulmonary Artery
Arterial Pressure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Pulmonary arterial hypertension : MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiacfunction, and ventricular remodeling. / Skrok, Jan; Shehata, Monda L.; Mathai, Stephen; Girgis, Reda E.; Zaiman, Ari; Mudd, James; Boyce, Danielle; Lechtzin, Noah; Lima, João A C; Bluemke, David A.; Hassoun, Paul M.; Vogel-Claussen, Jens.

In: Radiology, Vol. 263, No. 3, 2012, p. 678-687.

Research output: Contribution to journalArticle

Skrok, J, Shehata, ML, Mathai, S, Girgis, RE, Zaiman, A, Mudd, J, Boyce, D, Lechtzin, N, Lima, JAC, Bluemke, DA, Hassoun, PM & Vogel-Claussen, J 2012, 'Pulmonary arterial hypertension: MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiacfunction, and ventricular remodeling', Radiology, vol. 263, no. 3, pp. 678-687. https://doi.org/10.1148/radiol.12111001/-/DC1
Skrok, Jan ; Shehata, Monda L. ; Mathai, Stephen ; Girgis, Reda E. ; Zaiman, Ari ; Mudd, James ; Boyce, Danielle ; Lechtzin, Noah ; Lima, João A C ; Bluemke, David A. ; Hassoun, Paul M. ; Vogel-Claussen, Jens. / Pulmonary arterial hypertension : MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiacfunction, and ventricular remodeling. In: Radiology. 2012 ; Vol. 263, No. 3. pp. 678-687.
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abstract = "Purpose: To prospectively compare contrast material-enhanced (CE) magnetic resonance (MR) imaging-derived right-to-left ventricle pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) between patients with pulmonary arterial hypertension (PAH) and healthy volunteers and to correlate these measurements with survival markers in patients with PAH. Materials and Methods: This HIPAA-compliant study received institutional review board approval. Written informed consent was obtained from all participants. Forty-three patients (32 with PAH [29 women; median age, 55.4 years], 11 with scleroderma but not PAH [seven women; median age, 58.9 years]) underwent right-sided heart catheterization and 3-T CE cardiac MR imaging. Eighteen ageand sex-matched healthy control subjects (12 women; median age, 51.7 years) underwent only CE MR imaging. A short-axis saturation-recovery gradient-echo section was acquired in the basal third of both ventricles, and right-to-left-ventricle PTT, LV FWHM, and LV TTP were calculated. Statistical analysis included Kruskal-Wallis test, Wilcoxon rank sum test, Spearman correlation coefficient, multiple linear regression analysis, and Lin correlation coefficient analysis. Results: Patients had significantly longer PTT (median, 8.2 seconds; 25th-75th percentile, 6.9-9.9 seconds), FWHM (median, 8.2 seconds; 25th-75th percentile, 5.7-11.4 seconds), and TTP (median, 4.8 seconds; 25th-75th percentile, 3.9-6.5 seconds) than did control subjects (median, 6.4 seconds; 25th-75th percentile, 5.7-7.1 seconds; median, 5.2 seconds; 25th-75th percentile, 4.1-6.1 seconds; median, 3.2 seconds; 25th-75th percentile, 2.8-3.8 seconds, respectively; P <.01 for each) and subjects with scleroderma but not PAH (median, 6.5 seconds; 25th-75th percentile, 5.6-7.0 seconds; median, 5.0 seconds; 25th-75th percentile, 4.0-7.3 seconds; median, 3.6 seconds; 25th-75th percentile, 2.7-4.0 seconds, respectively; P <.02 for each). PTT, LV FWHM, and LV TTP correlated with pulmonary vascular resistance index (P <.01), right ventricular stroke volume index (P ≤ .01), and pulmonary artery capacitance (P ≤ .02). In multiple linear regression models, PTT, FWHM, and TTP were associated with mean pulmonary arterial pressure and cardiac index. Conclusion: CE MR-derived PTT, LV FWHM, and LV TTP are noninvasive compound markers of pulmonary hemodynamics and cardiac function in patients with PAH. Their predictive value for patient outcome warrants further investigation.",
author = "Jan Skrok and Shehata, {Monda L.} and Stephen Mathai and Girgis, {Reda E.} and Ari Zaiman and James Mudd and Danielle Boyce and Noah Lechtzin and Lima, {Jo{\~a}o A C} and Bluemke, {David A.} and Hassoun, {Paul M.} and Jens Vogel-Claussen",
year = "2012",
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TY - JOUR

T1 - Pulmonary arterial hypertension

T2 - MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiacfunction, and ventricular remodeling

AU - Skrok, Jan

AU - Shehata, Monda L.

AU - Mathai, Stephen

AU - Girgis, Reda E.

AU - Zaiman, Ari

AU - Mudd, James

AU - Boyce, Danielle

AU - Lechtzin, Noah

AU - Lima, João A C

AU - Bluemke, David A.

AU - Hassoun, Paul M.

AU - Vogel-Claussen, Jens

PY - 2012

Y1 - 2012

N2 - Purpose: To prospectively compare contrast material-enhanced (CE) magnetic resonance (MR) imaging-derived right-to-left ventricle pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) between patients with pulmonary arterial hypertension (PAH) and healthy volunteers and to correlate these measurements with survival markers in patients with PAH. Materials and Methods: This HIPAA-compliant study received institutional review board approval. Written informed consent was obtained from all participants. Forty-three patients (32 with PAH [29 women; median age, 55.4 years], 11 with scleroderma but not PAH [seven women; median age, 58.9 years]) underwent right-sided heart catheterization and 3-T CE cardiac MR imaging. Eighteen ageand sex-matched healthy control subjects (12 women; median age, 51.7 years) underwent only CE MR imaging. A short-axis saturation-recovery gradient-echo section was acquired in the basal third of both ventricles, and right-to-left-ventricle PTT, LV FWHM, and LV TTP were calculated. Statistical analysis included Kruskal-Wallis test, Wilcoxon rank sum test, Spearman correlation coefficient, multiple linear regression analysis, and Lin correlation coefficient analysis. Results: Patients had significantly longer PTT (median, 8.2 seconds; 25th-75th percentile, 6.9-9.9 seconds), FWHM (median, 8.2 seconds; 25th-75th percentile, 5.7-11.4 seconds), and TTP (median, 4.8 seconds; 25th-75th percentile, 3.9-6.5 seconds) than did control subjects (median, 6.4 seconds; 25th-75th percentile, 5.7-7.1 seconds; median, 5.2 seconds; 25th-75th percentile, 4.1-6.1 seconds; median, 3.2 seconds; 25th-75th percentile, 2.8-3.8 seconds, respectively; P <.01 for each) and subjects with scleroderma but not PAH (median, 6.5 seconds; 25th-75th percentile, 5.6-7.0 seconds; median, 5.0 seconds; 25th-75th percentile, 4.0-7.3 seconds; median, 3.6 seconds; 25th-75th percentile, 2.7-4.0 seconds, respectively; P <.02 for each). PTT, LV FWHM, and LV TTP correlated with pulmonary vascular resistance index (P <.01), right ventricular stroke volume index (P ≤ .01), and pulmonary artery capacitance (P ≤ .02). In multiple linear regression models, PTT, FWHM, and TTP were associated with mean pulmonary arterial pressure and cardiac index. Conclusion: CE MR-derived PTT, LV FWHM, and LV TTP are noninvasive compound markers of pulmonary hemodynamics and cardiac function in patients with PAH. Their predictive value for patient outcome warrants further investigation.

AB - Purpose: To prospectively compare contrast material-enhanced (CE) magnetic resonance (MR) imaging-derived right-to-left ventricle pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) between patients with pulmonary arterial hypertension (PAH) and healthy volunteers and to correlate these measurements with survival markers in patients with PAH. Materials and Methods: This HIPAA-compliant study received institutional review board approval. Written informed consent was obtained from all participants. Forty-three patients (32 with PAH [29 women; median age, 55.4 years], 11 with scleroderma but not PAH [seven women; median age, 58.9 years]) underwent right-sided heart catheterization and 3-T CE cardiac MR imaging. Eighteen ageand sex-matched healthy control subjects (12 women; median age, 51.7 years) underwent only CE MR imaging. A short-axis saturation-recovery gradient-echo section was acquired in the basal third of both ventricles, and right-to-left-ventricle PTT, LV FWHM, and LV TTP were calculated. Statistical analysis included Kruskal-Wallis test, Wilcoxon rank sum test, Spearman correlation coefficient, multiple linear regression analysis, and Lin correlation coefficient analysis. Results: Patients had significantly longer PTT (median, 8.2 seconds; 25th-75th percentile, 6.9-9.9 seconds), FWHM (median, 8.2 seconds; 25th-75th percentile, 5.7-11.4 seconds), and TTP (median, 4.8 seconds; 25th-75th percentile, 3.9-6.5 seconds) than did control subjects (median, 6.4 seconds; 25th-75th percentile, 5.7-7.1 seconds; median, 5.2 seconds; 25th-75th percentile, 4.1-6.1 seconds; median, 3.2 seconds; 25th-75th percentile, 2.8-3.8 seconds, respectively; P <.01 for each) and subjects with scleroderma but not PAH (median, 6.5 seconds; 25th-75th percentile, 5.6-7.0 seconds; median, 5.0 seconds; 25th-75th percentile, 4.0-7.3 seconds; median, 3.6 seconds; 25th-75th percentile, 2.7-4.0 seconds, respectively; P <.02 for each). PTT, LV FWHM, and LV TTP correlated with pulmonary vascular resistance index (P <.01), right ventricular stroke volume index (P ≤ .01), and pulmonary artery capacitance (P ≤ .02). In multiple linear regression models, PTT, FWHM, and TTP were associated with mean pulmonary arterial pressure and cardiac index. Conclusion: CE MR-derived PTT, LV FWHM, and LV TTP are noninvasive compound markers of pulmonary hemodynamics and cardiac function in patients with PAH. Their predictive value for patient outcome warrants further investigation.

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