Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria

Zhenjian Lin, Rowena R. Antemano, Ronald W. Hughen, Ma Diarey B. Tianero, Olivier Peraud, Margo G. Haygood, Gisela P. Concepcion, Baldomero M. Olivera, Alan Light, Eric W. Schmidt

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40 Scopus citations

Abstract

The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca2+ flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT2B receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.

Original languageEnglish (US)
Pages (from-to)1922-1926
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number11
DOIs
StatePublished - Nov 29 2010

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Lin, Z., Antemano, R. R., Hughen, R. W., Tianero, M. D. B., Peraud, O., Haygood, M. G., Concepcion, G. P., Olivera, B. M., Light, A., & Schmidt, E. W. (2010). Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of Natural Products, 73(11), 1922-1926. https://doi.org/10.1021/np100588c