Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria

Zhenjian Lin, Rowena R. Antemano, Ronald W. Hughen, Ma Diarey B Tianero, Olivier Peraud, Margo Haygood, Gisela P. Concepcion, Baldomero M. Olivera, Alan Light, Eric W. Schmidt

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca2+ flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT2B receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.

Original languageEnglish (US)
Pages (from-to)1922-1926
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number11
DOIs
StatePublished - Nov 29 2010

Fingerprint

Receptor, Serotonin, 5-HT2B
Snails
Metabolites
Biological Products
Neurons
Cones
Assays
Bacteria
Fluxes
Derivatives
Conus Snail
Philippines
Actinobacteria
Spinal Ganglia
Streptomyces
Ecosystem

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Lin, Z., Antemano, R. R., Hughen, R. W., Tianero, M. D. B., Peraud, O., Haygood, M., ... Schmidt, E. W. (2010). Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of Natural Products, 73(11), 1922-1926. https://doi.org/10.1021/np100588c

Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. / Lin, Zhenjian; Antemano, Rowena R.; Hughen, Ronald W.; Tianero, Ma Diarey B; Peraud, Olivier; Haygood, Margo; Concepcion, Gisela P.; Olivera, Baldomero M.; Light, Alan; Schmidt, Eric W.

In: Journal of Natural Products, Vol. 73, No. 11, 29.11.2010, p. 1922-1926.

Research output: Contribution to journalArticle

Lin, Z, Antemano, RR, Hughen, RW, Tianero, MDB, Peraud, O, Haygood, M, Concepcion, GP, Olivera, BM, Light, A & Schmidt, EW 2010, 'Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria', Journal of Natural Products, vol. 73, no. 11, pp. 1922-1926. https://doi.org/10.1021/np100588c
Lin Z, Antemano RR, Hughen RW, Tianero MDB, Peraud O, Haygood M et al. Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of Natural Products. 2010 Nov 29;73(11):1922-1926. https://doi.org/10.1021/np100588c
Lin, Zhenjian ; Antemano, Rowena R. ; Hughen, Ronald W. ; Tianero, Ma Diarey B ; Peraud, Olivier ; Haygood, Margo ; Concepcion, Gisela P. ; Olivera, Baldomero M. ; Light, Alan ; Schmidt, Eric W. / Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. In: Journal of Natural Products. 2010 ; Vol. 73, No. 11. pp. 1922-1926.
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