Psychosocial barriers and facilitators to clinical trial enrollment and adherence for adolescents with cancer

Natasha D. Buchanan, Rebecca Block, Ashley Wilder Smith, Eric Tai

    Research output: Contribution to journalReview article

    21 Scopus citations


    Adolescents (aged 15-19 years) have not experienced the same survival gains as children and older adults diagnosed with cancer. Poor clinical trial enrollment and adherence rates among adolescents may account for some of this disparity. Although biological, regulatory, systemic, and practice-related challenges to clinical trial enrollment and adherence have been examined, studies of psychosocial factors, which can serve as barriers or facilitators to enrollment and adherence, are limited. To bring attention to these psychological factors, we reviewed existing literature on psychosocial barriers and facilitators that can affect an adolescent's decision to enroll and adhere to a clinical trial. We also provide potential strategies to address psychosocial factors affecting clinical trial accrual and adherence.

    Original languageEnglish (US)
    Pages (from-to)S123-S130
    Issue numberSUPPL. 3
    StatePublished - Jun 1 2014



    • Adherence
    • Adolescent
    • Cancer survivors
    • Clinical trial
    • Enrollment
    • Psychosocial

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

    Cite this