Psychosis and Seizure Disorder: Challenges in Diagnosis and Treatment

Kamalika Roy, Richard Balon, Varma Penumetcha, B. Harrison Levine

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Psychosis temporally related to seizure episodes has been a recognized entity with much clinical attention, yet there are less clear guidelines for treatment. Presence of perceptual disturbances and cognitive impairment symptoms make the differentiation between primary psychoses and seizure- related psychoses blurred. Moreover, there are only a few reported cases describing clinical presentation, diagnostic dilemma and treatment challenges when these two entities are present at the same time, with overlapping symptomatology. We describe such a case where the presence of these two problems complicated the diagnoses and the patient’s subsequent management required a very intricate collaboration between psychiatry and neurology. In addition, we review available published articles including case reports, studies, and review articles regarding the diagnosis and treatment of this complicated clinical presentation. Some of the analyses were reviewed in detail and resulting outcomes are discussed. Finally, we review the diagnostic and treatment guidelines in the context of the presenting case.

Original languageEnglish (US)
Article number509
Pages (from-to)1-7
Number of pages7
JournalCurrent Psychiatry Reports
Issue number11
StatePublished - Nov 1 2014
Externally publishedYes


  • Anticonvulsants
  • Antipsychotics
  • Atypical
  • Complex partial seizures
  • EEG
  • Epilepsy
  • Ictal
  • Inter-ictal
  • MRI
  • Neurotransmitter
  • Post ictal
  • Psychosis
  • Schizophrenia
  • Seizure threshold

ASJC Scopus subject areas

  • Psychiatry and Mental health


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