Psychiatric implications of basic and clinical studies with corticotropin-releasing factor

P. W. Gold, G. Chrousos, C. Kellner, R. Post, A. Roy, P. Augerinos, H. Schulte, E. Oldfield, D. L. Loriaux

Research output: Contribution to journalArticle

387 Scopus citations

Abstract

Corticotropin-releasing factor (CRF) is a newly sequenced neuropeptide thought to be a principal stimulus to pituitary corticotropin (ACTH) secretion. Evidence obtained from laboratory animals and primates is reviewed which indicates that CRF not only stimulates the pituitary-adrenal axis but also influences several aspects of CNS function which may be of relevance to psychiatric illness. Clinically, experience in administering ovine CRF to more than 150 individuals shows that CRF can be helpful in resolving differential diagnostic dilemmas in patients with various disorders of the hypothalamic-pituitary-adrenal axis and in furthering an understanding of the pathophysiology of conditions such as Cushing's disease and depression.

Original languageEnglish (US)
Pages (from-to)619-627
Number of pages9
JournalAmerican Journal of Psychiatry
Volume141
Issue number5
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Gold, P. W., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., & Loriaux, D. L. (1984). Psychiatric implications of basic and clinical studies with corticotropin-releasing factor. American Journal of Psychiatry, 141(5), 619-627. https://doi.org/10.1176/ajp.141.5.619