Pseudomonas mendocina native valve infective endocarditis

a case report

Glenn J. Rapsinski, Jina Makadia, Nitin Bhanot, Zaw Min

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. Case presentation: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis. His past medical history included gout and chronic alcohol use. P. mendocina was isolated from his blood cultures. A comprehensive review of P. mendocina infection in the literature was performed. A total of eight cases of P. mendocina infection were reported in the literature. More than two-thirds of the cases of P. mendocina septicemia were associated with native valve infective endocarditis. Thus, an echocardiogram was performed and demonstrated mitral valve endocarditis with mild mitral insufficiency. His leg wounds were debrided and were probably the source of P. mendocina bacteremia. Unlike Pseudomonas aeruginosa, P. mendocina is susceptible to third-generation cephalosporins. Our patient received a 6-week course of antimicrobial therapy with a favorable clinical outcome. Conclusions: Our reported case and literature review illuminates a rare bacterial cause of infective endocarditis secondary to P. mendocina pathogen. Native cardiac valves were affected in all reported cases of infective endocarditis, and a majority of affected heart valves were left-sided. The antibiotics active against P. mendocina are different from those that are active against P. aeruginosa, and they notably include third-generation cephalosporins. The outcome of all reported cases of P. mendocina was favorable and no mortality was described.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Medical Case Reports
Volume10
Issue number1
DOIs
StatePublished - Oct 4 2016
Externally publishedYes

Fingerprint

Pseudomonas mendocina
Endocarditis
Pseudomonas Infections
Heart Valves
Cephalosporins
Pseudomonas aeruginosa
Leg Ulcer
Gout
Leukocytosis
Mitral Valve Insufficiency
Bacteremia
Mitral Valve

Keywords

  • Endocarditis
  • Pseudomonas mendocina infection
  • Pseudomonas mendocina septicemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pseudomonas mendocina native valve infective endocarditis : a case report. / Rapsinski, Glenn J.; Makadia, Jina; Bhanot, Nitin; Min, Zaw.

In: Journal of Medical Case Reports, Vol. 10, No. 1, 04.10.2016, p. 1-5.

Research output: Contribution to journalArticle

Rapsinski, Glenn J. ; Makadia, Jina ; Bhanot, Nitin ; Min, Zaw. / Pseudomonas mendocina native valve infective endocarditis : a case report. In: Journal of Medical Case Reports. 2016 ; Vol. 10, No. 1. pp. 1-5.
@article{978fcd0a49504ac0ac85623e88a55017,
title = "Pseudomonas mendocina native valve infective endocarditis: a case report",
abstract = "Background: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. Case presentation: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis. His past medical history included gout and chronic alcohol use. P. mendocina was isolated from his blood cultures. A comprehensive review of P. mendocina infection in the literature was performed. A total of eight cases of P. mendocina infection were reported in the literature. More than two-thirds of the cases of P. mendocina septicemia were associated with native valve infective endocarditis. Thus, an echocardiogram was performed and demonstrated mitral valve endocarditis with mild mitral insufficiency. His leg wounds were debrided and were probably the source of P. mendocina bacteremia. Unlike Pseudomonas aeruginosa, P. mendocina is susceptible to third-generation cephalosporins. Our patient received a 6-week course of antimicrobial therapy with a favorable clinical outcome. Conclusions: Our reported case and literature review illuminates a rare bacterial cause of infective endocarditis secondary to P. mendocina pathogen. Native cardiac valves were affected in all reported cases of infective endocarditis, and a majority of affected heart valves were left-sided. The antibiotics active against P. mendocina are different from those that are active against P. aeruginosa, and they notably include third-generation cephalosporins. The outcome of all reported cases of P. mendocina was favorable and no mortality was described.",
keywords = "Endocarditis, Pseudomonas mendocina infection, Pseudomonas mendocina septicemia",
author = "Rapsinski, {Glenn J.} and Jina Makadia and Nitin Bhanot and Zaw Min",
year = "2016",
month = "10",
day = "4",
doi = "10.1186/s13256-016-1057-6",
language = "English (US)",
volume = "10",
pages = "1--5",
journal = "Journal of Medical Case Reports",
issn = "1752-1947",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Pseudomonas mendocina native valve infective endocarditis

T2 - a case report

AU - Rapsinski, Glenn J.

AU - Makadia, Jina

AU - Bhanot, Nitin

AU - Min, Zaw

PY - 2016/10/4

Y1 - 2016/10/4

N2 - Background: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. Case presentation: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis. His past medical history included gout and chronic alcohol use. P. mendocina was isolated from his blood cultures. A comprehensive review of P. mendocina infection in the literature was performed. A total of eight cases of P. mendocina infection were reported in the literature. More than two-thirds of the cases of P. mendocina septicemia were associated with native valve infective endocarditis. Thus, an echocardiogram was performed and demonstrated mitral valve endocarditis with mild mitral insufficiency. His leg wounds were debrided and were probably the source of P. mendocina bacteremia. Unlike Pseudomonas aeruginosa, P. mendocina is susceptible to third-generation cephalosporins. Our patient received a 6-week course of antimicrobial therapy with a favorable clinical outcome. Conclusions: Our reported case and literature review illuminates a rare bacterial cause of infective endocarditis secondary to P. mendocina pathogen. Native cardiac valves were affected in all reported cases of infective endocarditis, and a majority of affected heart valves were left-sided. The antibiotics active against P. mendocina are different from those that are active against P. aeruginosa, and they notably include third-generation cephalosporins. The outcome of all reported cases of P. mendocina was favorable and no mortality was described.

AB - Background: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. Case presentation: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis. His past medical history included gout and chronic alcohol use. P. mendocina was isolated from his blood cultures. A comprehensive review of P. mendocina infection in the literature was performed. A total of eight cases of P. mendocina infection were reported in the literature. More than two-thirds of the cases of P. mendocina septicemia were associated with native valve infective endocarditis. Thus, an echocardiogram was performed and demonstrated mitral valve endocarditis with mild mitral insufficiency. His leg wounds were debrided and were probably the source of P. mendocina bacteremia. Unlike Pseudomonas aeruginosa, P. mendocina is susceptible to third-generation cephalosporins. Our patient received a 6-week course of antimicrobial therapy with a favorable clinical outcome. Conclusions: Our reported case and literature review illuminates a rare bacterial cause of infective endocarditis secondary to P. mendocina pathogen. Native cardiac valves were affected in all reported cases of infective endocarditis, and a majority of affected heart valves were left-sided. The antibiotics active against P. mendocina are different from those that are active against P. aeruginosa, and they notably include third-generation cephalosporins. The outcome of all reported cases of P. mendocina was favorable and no mortality was described.

KW - Endocarditis

KW - Pseudomonas mendocina infection

KW - Pseudomonas mendocina septicemia

UR - http://www.scopus.com/inward/record.url?scp=84989809987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989809987&partnerID=8YFLogxK

U2 - 10.1186/s13256-016-1057-6

DO - 10.1186/s13256-016-1057-6

M3 - Article

VL - 10

SP - 1

EP - 5

JO - Journal of Medical Case Reports

JF - Journal of Medical Case Reports

SN - 1752-1947

IS - 1

ER -