Pseudoepithelialization of Breast Implant Capsules

Donald R. Chase, Kerby C. Oberg, Resa L. Chase, Richelle Malott, Douglas Weeks

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A review of 11 breast implant capsules revealed that 5 (45%) possessed a pseudoepithe lial lining virtually indistinguishable morphologically from true synovium. These cap sules showed a spectrum of connective tissue metaplasia that culminated in an ex tremely well-ordered double layer of columnar-appearing cells marking only for vimentin intermediate filaments and failing to stain for various cytokeratins and human factor VIII. Neither trichrome stains nor electron microscopy showed evidence of a basement membrane. The cases indicate that under appropriate conditions breast tissues can undergo mesenchymal metaplasia as well as the much more common epithelial metaplasia. Furthermore, a process morphologically identical to that previ ously described as “synovial metaplasia” in other locations also occurs in some breast capsules where, as in the dermis and in periarticular sites, its development may be dependent upon local factors such as friction and micromotion. Int J Surg Pathol 1 (3): 151-154, 1994

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalInternational Journal of Surgical Pathology
Volume1
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Breast Implants
Metaplasia
Capsules
Breast
Intermediate Filaments
Friction
Synovial Membrane
Vimentin
Dermis
Keratins
Basement Membrane
Connective Tissue
Electron Microscopy
Coloring Agents

Keywords

  • breast implant capsules
  • immunohistochemistry
  • mesenchymal metaplasia
  • pseudoepithelium
  • synovial metaplasia

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Pseudoepithelialization of Breast Implant Capsules. / Chase, Donald R.; Oberg, Kerby C.; Chase, Resa L.; Malott, Richelle; Weeks, Douglas.

In: International Journal of Surgical Pathology, Vol. 1, No. 3, 1994, p. 151-154.

Research output: Contribution to journalArticle

Chase, Donald R. ; Oberg, Kerby C. ; Chase, Resa L. ; Malott, Richelle ; Weeks, Douglas. / Pseudoepithelialization of Breast Implant Capsules. In: International Journal of Surgical Pathology. 1994 ; Vol. 1, No. 3. pp. 151-154.
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