Pruritic dermatitis in asthmatic basenji-greyhound dogs: A model for human atopic dermatitis

J. M. Butler, J. E. Peters, C. A. Hirshman, Clifton White, L. B. Margolin, Jon Hanifin

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume8
Issue number1
DOIs
StatePublished - 1983

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Dermatitis
Atopic Dermatitis
Dogs
SRS-A
Ascaris
Histamine Release
Mechanics
Aerosols
Cyclic AMP
Adrenergic Agents
Asthma
Animal Models
Antigens
Lung

ASJC Scopus subject areas

  • Dermatology

Cite this

Pruritic dermatitis in asthmatic basenji-greyhound dogs : A model for human atopic dermatitis. / Butler, J. M.; Peters, J. E.; Hirshman, C. A.; White, Clifton; Margolin, L. B.; Hanifin, Jon.

In: Journal of the American Academy of Dermatology, Vol. 8, No. 1, 1983, p. 33-38.

Research output: Contribution to journalArticle

Butler, J. M. ; Peters, J. E. ; Hirshman, C. A. ; White, Clifton ; Margolin, L. B. ; Hanifin, Jon. / Pruritic dermatitis in asthmatic basenji-greyhound dogs : A model for human atopic dermatitis. In: Journal of the American Academy of Dermatology. 1983 ; Vol. 8, No. 1. pp. 33-38.
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