Pruritic dermatitis in asthmatic basenji-greyhound dogs: A model for human atopic dermatitis

James M. Butler, James E. Peters, Carol A. Hirshman, Clifton R. White, Leonid B. Margolin, Jon M. Hanifin

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Dermatology

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