Proton MR spectroscopy correlates of frontal lobe function in healthy children

Arzu Ozturk, M. Degaonkar, M. A. Matson, C. T. Wells, E. M. Mahone, Alena Horská

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Neuroimaging methods have been used to improve our understanding of the topographic organization of the brain. In our study, proton 1H-MR spectroscopic imaging was used to evaluate frontal lobe function. The goal was to determine the relationship between neuropsychological measures of frontal lobe function and levels of a surrogate neuronal marker, N-acetylaspartate (NAA), in typically developing healthy children and adolescents. MATERIALS AND METHODS: Fifty-one healthy children (25 girls; 6.2-18.3 years of age; mean age, 12.3 ± 3.6 years) were examined. All children completed a neuropsychological assessment including measures of attention, executive function, memory, language, and visual and motor skills. 1H-MR spectroscopic imaging was performed by using a multisection spin-echo sequence at 1.5T. General linear model analysis of covariance was used to examine the relationship between the neuropsychological test scores and NAA/creatine (Cr) ratios, controlling for age and sex. RESULTS: A positive relationship between frontal lobe white matter NAA/Cr ratio and performance on 2 neuropsychological tests associated with frontal lobe function was detected. The Purdue Pegboard right-hand scores were higher with increasing NAA/Cr in the left frontal white matter (P = .047), and Stanford-Binet-IV "Bead Memory" scores improved with increasing NAA/Cr ratio in the right frontal white matter (P = .032). CONCLUSIONS: An association between frontal white matter NAA/Cr ratios and 1) measures of manual speed and dexterity, and 2) visual working memory was detected. Our data may provide a quantitative basis for assessment of frontal lobe impairments in disease states.

Original languageEnglish (US)
Pages (from-to)1308-1314
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume30
Issue number7
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Frontal Lobe
Creatine
Protons
Magnetic Resonance Spectroscopy
Neuropsychological Tests
Motor Skills
Executive Function
Short-Term Memory
Neuroimaging
N-acetylaspartate
Linear Models
Language
Hand
Biomarkers
White Matter
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Ozturk, A., Degaonkar, M., Matson, M. A., Wells, C. T., Mahone, E. M., & Horská, A. (2009). Proton MR spectroscopy correlates of frontal lobe function in healthy children. American Journal of Neuroradiology, 30(7), 1308-1314. https://doi.org/10.3174/ajnr.A1576

Proton MR spectroscopy correlates of frontal lobe function in healthy children. / Ozturk, Arzu; Degaonkar, M.; Matson, M. A.; Wells, C. T.; Mahone, E. M.; Horská, Alena.

In: American Journal of Neuroradiology, Vol. 30, No. 7, 08.2009, p. 1308-1314.

Research output: Contribution to journalArticle

Ozturk, A, Degaonkar, M, Matson, MA, Wells, CT, Mahone, EM & Horská, A 2009, 'Proton MR spectroscopy correlates of frontal lobe function in healthy children', American Journal of Neuroradiology, vol. 30, no. 7, pp. 1308-1314. https://doi.org/10.3174/ajnr.A1576
Ozturk, Arzu ; Degaonkar, M. ; Matson, M. A. ; Wells, C. T. ; Mahone, E. M. ; Horská, Alena. / Proton MR spectroscopy correlates of frontal lobe function in healthy children. In: American Journal of Neuroradiology. 2009 ; Vol. 30, No. 7. pp. 1308-1314.
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