Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues: A Model Study

Nancy H. Kolodny, Evangelos S. Gragoudas, Donald J. D'amico, Susan J. Kohler, Johanna M. Seddon, Elizabeth J. Murphy, Christina Yun, Daniel Albert

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Clinical evaluation of uveal melanomas by magnetic resonance imaging (MRI) techniques depends on developing an understanding of the appearance of these tumors in magnetic resonance (MR) images. We have determined MR characteristics of uveal melanomas by proton (1H) and sodium 23 MRI of freshly enucleated human eyes at 1.5 tesla. The MR images were obtained using two-turn proton and 23Na surface coils, designed to both transmit and receive the radiofrequency signal. Proton MRI techniques included saturation recovery and spin echo; the gradient-recalled echo technique was used for 23Na MRI. Proton and 23Na MR images provide complementary information; contrast between intraocular tumors and vitreous, lens, or subretinal hemorrhage may be varied by using MR pulse sequences that emphasize tissues based on T1, T2, proton, or sodium density values. A combination of proton and 23Na MRI provides differentiation between normal ocular structures and intraocular tumors, as well as associated complications, such as retinal detachments and subretinal hemorrhages.

Original languageEnglish (US)
Pages (from-to)1532-1536
Number of pages5
JournalArchives of ophthalmology
Volume105
Issue number11
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Protons
Sodium
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Hemorrhage
Neoplasms
Retinal Detachment
Lenses
Uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kolodny, N. H., Gragoudas, E. S., D'amico, D. J., Kohler, S. J., Seddon, J. M., Murphy, E. J., ... Albert, D. (1987). Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues: A Model Study. Archives of ophthalmology, 105(11), 1532-1536. https://doi.org/10.1001/archopht.1987.01060110078036

Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues : A Model Study. / Kolodny, Nancy H.; Gragoudas, Evangelos S.; D'amico, Donald J.; Kohler, Susan J.; Seddon, Johanna M.; Murphy, Elizabeth J.; Yun, Christina; Albert, Daniel.

In: Archives of ophthalmology, Vol. 105, No. 11, 01.01.1987, p. 1532-1536.

Research output: Contribution to journalArticle

Kolodny, NH, Gragoudas, ES, D'amico, DJ, Kohler, SJ, Seddon, JM, Murphy, EJ, Yun, C & Albert, D 1987, 'Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues: A Model Study', Archives of ophthalmology, vol. 105, no. 11, pp. 1532-1536. https://doi.org/10.1001/archopht.1987.01060110078036
Kolodny NH, Gragoudas ES, D'amico DJ, Kohler SJ, Seddon JM, Murphy EJ et al. Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues: A Model Study. Archives of ophthalmology. 1987 Jan 1;105(11):1532-1536. https://doi.org/10.1001/archopht.1987.01060110078036
Kolodny, Nancy H. ; Gragoudas, Evangelos S. ; D'amico, Donald J. ; Kohler, Susan J. ; Seddon, Johanna M. ; Murphy, Elizabeth J. ; Yun, Christina ; Albert, Daniel. / Proton and Sodium 23 Magnetic Resonance Imaging of Human Ocular Tissues : A Model Study. In: Archives of ophthalmology. 1987 ; Vol. 105, No. 11. pp. 1532-1536.
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