Prothrombin G20210A and factor V Leiden polymorphisms in stroke

Thierry Paluku They-They, Omar Battas, Ilham Slassi, Mohamed Abdou Rafai, Desire Tshala Katumbay, Sellama Nadifi

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The molecular epidemiology of stroke is critically lacking in the developing world. We explored the relationships between genetics polymorphism and risk for ischemic stroke among the residents of Casablanca, Morocco. Ninety-one stroke patients matched 1:2 for their age, gender, and ethnic background to 182 healthy controls who were genotyped for the prothrombin G20210A mutation and factor V (FV) Leiden and were assessed for conventional risk factors for stroke. No significant association was found between prothrombin gene mutation with stroke (p=.054). Regarding stroke subtypes, significant relationships between patients with a large artery disease subtype of stroke and this mutation was found compared to controls (p=.046). As a genetic risk factor to develop this event, a strong association was observed when adjusted for conventional vascular risk factors (adjusted OR, 4.3; p=.029). No FV Leiden was found. We suggest that prothrombin mutation but not FV Leiden should be considered as a modest genetic risk factor for large artery disease stroke subtype in the Moroccan population.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalJournal of Molecular Neuroscience
Volume46
Issue number1
DOIs
StatePublished - Feb 2012

Keywords

  • Factor V Leiden
  • Genetic polymorphism
  • Prothrombin
  • Stroke
  • Thrombosis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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