Proteomic approaches for the identification of cell cycle-related drug targets.

Mark Flory, Ruedi Aebersold

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Drugs affecting the cell cycle provide insights into mechanisms underlying cancer and suggest strategies for ablating uncontrolled growth. Essential to an understanding of the activity of such compounds is the identification of the set of proteins affected, either directly or indirectly, by the drug. The combination of novel technologies for stable isotope protein tagging, chromatographic separation, tandem mass spectrometry, and data processing is an extremely powerful means for providing such identifications and, in addition, for establishing a proteome-wide profile of all proteins whose abundance levels or phosphorylation state are affected by the drug.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalProgress in cell cycle research
Volume5
StatePublished - Jan 1 2003
Externally publishedYes

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Proteomics
Cell Cycle
Pharmaceutical Preparations
Proteins
Proteome
Tandem Mass Spectrometry
Isotopes
Phosphorylation
Technology
Growth
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Proteomic approaches for the identification of cell cycle-related drug targets. / Flory, Mark; Aebersold, Ruedi.

In: Progress in cell cycle research, Vol. 5, 01.01.2003, p. 167-171.

Research output: Contribution to journalReview article

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