@article{34cae294339d401184153842d03233c3,
title = "Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer",
abstract = "McGrail et al. find that the abundance of destabilizing mutations in microsatellite unstable (MSI) tumors causes proteome instability and accumulation of misfolded proteins. To compensate, MSI tumors rely on a Nedd8-mediated pathway to clear misfolded aggregates, which can be therapeutically targeted by MLN4924.",
keywords = "colorectal cancer (COAD), endometrial cancer (UCEC), immunotherapy, microsatellite instability (MSI), mismatch repair (MMR), neddylation, protein degredation, protein homeostasis",
author = "McGrail, {Daniel J.} and Jeannine Garnett and Jun Yin and Hui Dai and Shih, {David J.H.} and Lam, {Truong Nguyen Anh} and Yang Li and Chaoyang Sun and Yongsheng Li and Rosemarie Schmandt and Wu, {Ji Yuan} and Limei Hu and Yulong Liang and Guang Peng and Eric Jonasch and David Menter and Yates, {Melinda S.} and Scott Kopetz and Lu, {Karen H.} and Russell Broaddus and Mills, {Gordon B.} and Nidhi Sahni and Lin, {Shiaw Yih}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = mar,
day = "16",
doi = "10.1016/j.ccell.2020.01.011",
language = "English (US)",
volume = "37",
pages = "371--386.e12",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}