Proteins that interact with the pore-forming subunits of voltage-gated ion channels

John P. Adelman

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messenger systems influence the voltage-gated ion channels, only in a few cases has clear evidence for direct protein-protein interactions been demonstrated. Recent biochemical and genetic studies have helped to elucidate the scope of the interactions between these ion channels and various modulatory proteins by determining the structures and functions of nonpore-forming subunits.

Original languageEnglish (US)
Pages (from-to)286-295
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume5
Issue number3
DOIs
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Proteins that interact with the pore-forming subunits of voltage-gated ion channels'. Together they form a unique fingerprint.

  • Cite this