Protein tyrosine kinases and cancer

Kathryn S. Kolibaba, Brian J. Druker

Research output: Contribution to journalReview article

265 Scopus citations

Abstract

The ABL, PDGFR, RET, and ALK tyrosine kinases have been clearly implicated in the etiology of human malignancies. However, in other tumors, distinguishing between tyrosine kinases as causative agents, as opposed to markers of disease progression or reflections of aberrant tumor cells, has proven difficult. In the absence of a genetic mutation in a tyrosine kinase, it has been difficult to confirm a role for various tyrosine kinases in most malignant human diseases. Given the central role of tyrosine kinases in the control of cellular growth and differentiation, however, it is likely that tyrosine kinases will be shown to participate in crucial aspects of tumorigenesis, some of which may provide fruitful avenues for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)F217-F248
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1333
Issue number3
DOIs
StatePublished - Dec 9 1997

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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