Protein translocation as a tool: The current rapamycin story

Mateusz Putyrski; Carsten Schultz

doi:10.1016/j.febslet.2012.04.061

Protein translocation as a tool: The current rapamycin story

Mateusz Putyrski, Carsten Schultz

Research output: Contribution to journal › Review article › peer-review

137 Scopus citations

Abstract

In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.

Original language	English (US)
Pages (from-to)	2097-2105
Number of pages	9
Journal	FEBS Letters
Volume	586
Issue number	15
DOIs	https://doi.org/10.1016/j.febslet.2012.04.061
State	Published - Jul 16 2012
Externally published	Yes

Keywords

Chemical dimerizer
Protein translocation
Protein-protein interaction
Rapamycin
Signal transduction

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2012.04.061

Cite this

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title = "Protein translocation as a tool: The current rapamycin story",

abstract = "In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.",

keywords = "Chemical dimerizer, Protein translocation, Protein-protein interaction, Rapamycin, Signal transduction",

author = "Mateusz Putyrski and Carsten Schultz",

note = "Funding Information: We apologize for not being able to mention all relevant work in the field due to space restrictions. Work of the Schultz lab is funded by the EMBL, the ESF (EuroMembrane TraPPs, Schu 943/7-1), the DFG (Transregio 83), the Helmholtz Association (SBCancer and LungSysII), the German Lung Research Center and the EU (Integrated project LIVIMODE). The authors declare no competing financial interests.",

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doi = "10.1016/j.febslet.2012.04.061",

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T2 - The current rapamycin story

AU - Putyrski, Mateusz

AU - Schultz, Carsten

N1 - Funding Information: We apologize for not being able to mention all relevant work in the field due to space restrictions. Work of the Schultz lab is funded by the EMBL, the ESF (EuroMembrane TraPPs, Schu 943/7-1), the DFG (Transregio 83), the Helmholtz Association (SBCancer and LungSysII), the German Lung Research Center and the EU (Integrated project LIVIMODE). The authors declare no competing financial interests.

PY - 2012/7/16

Y1 - 2012/7/16

N2 - In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.

AB - In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.

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KW - Protein translocation

KW - Protein-protein interaction

KW - Rapamycin

KW - Signal transduction

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Protein translocation as a tool: The current rapamycin story

Abstract

Keywords

ASJC Scopus subject areas

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