Protein translocation as a tool: The current rapamycin story

Mateusz Putyrski, Carsten Schultz

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.

Original languageEnglish (US)
Pages (from-to)2097-2105
Number of pages9
JournalFEBS Letters
Volume586
Issue number15
DOIs
StatePublished - Jul 16 2012
Externally publishedYes

Fingerprint

Protein Transport
Sirolimus
Cytology
Dimerization
Enzyme activity
Enzymes
Immunosuppressive Agents
Cell Biology
Proteins
Pharmacology
Derivatives

Keywords

  • Chemical dimerizer
  • Protein translocation
  • Protein-protein interaction
  • Rapamycin
  • Signal transduction

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Protein translocation as a tool : The current rapamycin story. / Putyrski, Mateusz; Schultz, Carsten.

In: FEBS Letters, Vol. 586, No. 15, 16.07.2012, p. 2097-2105.

Research output: Contribution to journalReview article

Putyrski, Mateusz ; Schultz, Carsten. / Protein translocation as a tool : The current rapamycin story. In: FEBS Letters. 2012 ; Vol. 586, No. 15. pp. 2097-2105.
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