Protein-losing enteropathy in systemic lupus erythematosus - Diagnosis and monitoring immunosuppressive therapy by alpha-1-antitrypsin clearance in stool

Kent G. Benner, Anthony Montanaro

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Enteric protein loss resulting in profound hypoalbuminemia and anasarca is an uncommon manifestation of systemic lupus erythematosus and only rarely is the initial presentation of disease. A few patients with SLE and protein-losing enteropathy in the absence of increased central venous pressure or intestinal lymphangiectasia have been reported. We describe the utility alpha-1-antitrypsin clearance in stool for diagnosing and monitoring enteric protein loss during successful immunosuppressive drug therapy in a patient who presented with massive enteric protein loss as the initial manifestation of systemic lupus erythematosus.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalDigestive Diseases and Sciences
Volume34
Issue number1
DOIs
StatePublished - Jan 1989

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Protein-Losing Enteropathies
alpha 1-Antitrypsin
Immunosuppressive Agents
Systemic Lupus Erythematosus
Intestinal Lymphangiectasis
Hypoalbuminemia
Proteins
Central Venous Pressure
Edema
Therapeutics
Drug Therapy

Keywords

  • α-1-antitrypsin clearance
  • hypoalbuminemia
  • protein-losing enteropathy
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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N2 - Enteric protein loss resulting in profound hypoalbuminemia and anasarca is an uncommon manifestation of systemic lupus erythematosus and only rarely is the initial presentation of disease. A few patients with SLE and protein-losing enteropathy in the absence of increased central venous pressure or intestinal lymphangiectasia have been reported. We describe the utility alpha-1-antitrypsin clearance in stool for diagnosing and monitoring enteric protein loss during successful immunosuppressive drug therapy in a patient who presented with massive enteric protein loss as the initial manifestation of systemic lupus erythematosus.

AB - Enteric protein loss resulting in profound hypoalbuminemia and anasarca is an uncommon manifestation of systemic lupus erythematosus and only rarely is the initial presentation of disease. A few patients with SLE and protein-losing enteropathy in the absence of increased central venous pressure or intestinal lymphangiectasia have been reported. We describe the utility alpha-1-antitrypsin clearance in stool for diagnosing and monitoring enteric protein loss during successful immunosuppressive drug therapy in a patient who presented with massive enteric protein loss as the initial manifestation of systemic lupus erythematosus.

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