Protective properties of peptidoglycan associated protein of Shigella flexneri.

M. Mulczyk, G. Adamus, D. Witkowska

Research output: Contribution to journalArticle

Abstract

Groups of CH3/Hej mice were immunized with peptidoglycan associated protein (PGP) from Shigella flexneri 3a administered in a single intraperitoneal injection (5 micrograms per mouse). After various periods post immunization the animals were challenged intraperitoneally with homologous bacteria. PGP proved to be strongly immunogenic. As early as one week after immunization all the animals survived challenge with 100 X LD100, and one third of the animals survived challenge with a dose of 500 X LD100. This high state of immunity maintained at almost unaltered intensity for 12 weeks after immunization (the end of the observations period).

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume32
Issue number5
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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