Protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of Shigella spp.

G. Adamus, M. Mulczyk, D. Witkowska, E. Romanowska

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Active immunization of guinea pigs and rabbits with outer membrane proteins (OMP) isolated from Shigella flexneri 3a and Shigella sonnei phase I protected the animals against keratoconjunctivitis shigellosa induced with the homologous or heterologous strain. Protection was also achieved in rabbits after passive immunization with anti-OMP immune serum. Active immunization with lipopolysaccharide of S. flexneri 3a did not protect rabbits against keratoconjunctivitis shigellosa.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalInfection and Immunity
Issue number2
StatePublished - Jan 1 1980


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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