Proteasomes are regulated by interferon γ: Implications for antigen processing

Y. Yang, J. B. Waters, K. Fruh, P. A. Peterson

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

Class I major histocompatibility complex (MHC) molecules present antigenic peptides of cytoplasmic origin to T cells. As the lengths of these peptides seem restricted to eight or nine amino acids, an unusual proteolytic system must play a role in antigen processing. Proteasomes, a major extralysosomal proteolytic system, are responsible for the degradation of cytoplasmic proteins. We demonstrate that several proteasomal subunits, including MHC- encoded subunits, are regulated by interferon γ. These data and the finding that MHC-encoded and other interferon γ-regulated proteasomal subunits are uniquely associated with proteasomes strongly suggest that the immune system has recruited proteasomes for antigen processing.

Original languageEnglish (US)
Pages (from-to)4928-4932
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number11
DOIs
StatePublished - 1992

Keywords

  • class I molecules
  • lymphokines
  • major histocompatibility complex

ASJC Scopus subject areas

  • General

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