Proteases, Extracellular Matrix, and Cancer

A Workshop of the Path B Study Section

Yves A. DeClerck, Arthur M. Mercurio, M. Sharon Stack, Harold A. Chapman, Mary M. Zutter, Ruth J. Muschel, Avraham Raz, Lynn M. Matrisian, Bonnie F. Sloane, Agnes Noel, Mary J. Hendrix, Lisa Coussens, Martin Padarathsingh

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and activity of many growth factors, growth factor receptors, and cytokines are modified. ECM-degrading proteases also play a critical role in angiogenesis, where they can act as positive as well as negative regulators of endothelial cell proliferation and vascular morphogenesis. This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002.

Original languageEnglish (US)
Pages (from-to)1131-1139
Number of pages9
JournalAmerican Journal of Pathology
Volume164
Issue number4
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Extracellular Matrix
Peptide Hydrolases
Education
Neoplasms
Intercellular Signaling Peptides and Proteins
Tumor Microenvironment
Growth Factor Receptors
National Institutes of Health (U.S.)
Morphogenesis
Biological Availability
Blood Vessels
Carrier Proteins
Endothelial Cells
Cell Proliferation
Cytokines

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

DeClerck, Y. A., Mercurio, A. M., Stack, M. S., Chapman, H. A., Zutter, M. M., Muschel, R. J., ... Padarathsingh, M. (2004). Proteases, Extracellular Matrix, and Cancer: A Workshop of the Path B Study Section. American Journal of Pathology, 164(4), 1131-1139.

Proteases, Extracellular Matrix, and Cancer : A Workshop of the Path B Study Section. / DeClerck, Yves A.; Mercurio, Arthur M.; Stack, M. Sharon; Chapman, Harold A.; Zutter, Mary M.; Muschel, Ruth J.; Raz, Avraham; Matrisian, Lynn M.; Sloane, Bonnie F.; Noel, Agnes; Hendrix, Mary J.; Coussens, Lisa; Padarathsingh, Martin.

In: American Journal of Pathology, Vol. 164, No. 4, 04.2004, p. 1131-1139.

Research output: Contribution to journalArticle

DeClerck, YA, Mercurio, AM, Stack, MS, Chapman, HA, Zutter, MM, Muschel, RJ, Raz, A, Matrisian, LM, Sloane, BF, Noel, A, Hendrix, MJ, Coussens, L & Padarathsingh, M 2004, 'Proteases, Extracellular Matrix, and Cancer: A Workshop of the Path B Study Section', American Journal of Pathology, vol. 164, no. 4, pp. 1131-1139.
DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ et al. Proteases, Extracellular Matrix, and Cancer: A Workshop of the Path B Study Section. American Journal of Pathology. 2004 Apr;164(4):1131-1139.
DeClerck, Yves A. ; Mercurio, Arthur M. ; Stack, M. Sharon ; Chapman, Harold A. ; Zutter, Mary M. ; Muschel, Ruth J. ; Raz, Avraham ; Matrisian, Lynn M. ; Sloane, Bonnie F. ; Noel, Agnes ; Hendrix, Mary J. ; Coussens, Lisa ; Padarathsingh, Martin. / Proteases, Extracellular Matrix, and Cancer : A Workshop of the Path B Study Section. In: American Journal of Pathology. 2004 ; Vol. 164, No. 4. pp. 1131-1139.
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