Protean permeases

Diverse roles for membrane transport proteins in kinetoplastid protozoa

Research output: Contribution to journalReview article

Abstract

Kinetoplastid parasites such as Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species rely upon their insect and vertebrate hosts to provide a plethora of nutrients throughout their life cycles. Nutrients and ions critical for parasite survival are taken up across the parasite plasma membrane by transporters and channels, polytopic membrane proteins that provide substrate-specific pores across the hydrophobic barrier. However, transporters and channels serve a wide range of biological functions beyond uptake of nutrients. This article highlights the diversity of activities that these integral membrane proteins serve and underscores the emerging complexity of their functions.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalMolecular and Biochemical Parasitology
Volume227
DOIs
StatePublished - Jan 1 2019

Fingerprint

Membrane Transport Proteins
Parasites
Food
Membrane Proteins
Trypanosoma brucei brucei
Trypanosoma cruzi
Leishmania
Life Cycle Stages
Ion Channels
Insects
Vertebrates
Cell Membrane
Ions

Keywords

  • Channels
  • Drug sensitivity
  • Kinetoplastid parasites
  • Organelles
  • Sensing
  • Transporters

ASJC Scopus subject areas

  • Parasitology
  • Molecular Biology

Cite this

Protean permeases : Diverse roles for membrane transport proteins in kinetoplastid protozoa. / Landfear, Scott.

In: Molecular and Biochemical Parasitology, Vol. 227, 01.01.2019, p. 39-46.

Research output: Contribution to journalReview article

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