Prosthetic valvular endocarditis: A 12 year review

L. Slaughter, J. E. Morris, Albert Starr

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

A retrospective examination was made of a total of 48 patients with infected prosthetic cardiac valves implanted in 1,236 patients. Survival rate of the valvular infections was 40%. The purpose of the study was to determine the factors which aided or decreased patient survival and to develop a program of treatment with antimicrobial agents. Numerous antimicrobics and a variety of dosage schedules were used. Of 19 surviving patients, medical treatment alone was effective in 14, despite the continued presence of a valvular prosthesis. Reoperation was successful in 5 of 9 patients. Lifelong chemoprophylactic or suppressive therapy was shown to be unnecessary to prevent relapse in 12 survivors. Prompt surgical replacement is indicated if antimicrobial therapy fails to eradicate infection of a prosthetic valve. A more systematic approach to antimicrobial therapy should improve survival of medically treated infections. Recommendations are made for prevention and treatment of prosthetic valvular endocarditis.

Original languageEnglish (US)
Pages (from-to)1319-1326
Number of pages8
JournalCirculation
Volume47
Issue number6
StatePublished - 1973

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compound A 12
Endocarditis
Therapeutics
Infection
Survival
Heart Valves
Anti-Infective Agents
Reoperation
Prostheses and Implants
Survivors
Appointments and Schedules
Survival Rate
Recurrence

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Slaughter, L., Morris, J. E., & Starr, A. (1973). Prosthetic valvular endocarditis: A 12 year review. Circulation, 47(6), 1319-1326.

Prosthetic valvular endocarditis : A 12 year review. / Slaughter, L.; Morris, J. E.; Starr, Albert.

In: Circulation, Vol. 47, No. 6, 1973, p. 1319-1326.

Research output: Contribution to journalArticle

Slaughter, L, Morris, JE & Starr, A 1973, 'Prosthetic valvular endocarditis: A 12 year review', Circulation, vol. 47, no. 6, pp. 1319-1326.
Slaughter L, Morris JE, Starr A. Prosthetic valvular endocarditis: A 12 year review. Circulation. 1973;47(6):1319-1326.
Slaughter, L. ; Morris, J. E. ; Starr, Albert. / Prosthetic valvular endocarditis : A 12 year review. In: Circulation. 1973 ; Vol. 47, No. 6. pp. 1319-1326.
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