Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer

Ken Ryu Han, David B. Seligson, Xueli Liu, Steve Horvath, Peter I. Shintaku, George Thomas, Jonathan W. Said, Robert E. Reiter

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Purpose: Few successful therapeutic options exist for men who present with metastatic prostate cancer (CaP) or for the 30% with recurrence. The development and characterization of molecular markers are vital to the development of prognostic and therapeutic modalities in CaP. We investigated the expression and potential clinical usefulness of prostate stem cell antigen (PSCA) in CaP using tissue microarrays. Materials and Methods: Immunohistochemical analysis using a PSCA monoclonal antibody was performed on tissue microarrays constructed from paraffin embedded specimens from 246 patients who underwent radical retropubic prostatectomy. PSCA staining was correlated with established prognostic factors, such as Gleason score, prostate specific antigen (PSA), and seminal vesicle invasion. In addition, recurrence-free survival was analyzed. Results: A high PSCA intensity of 3 was associated with adverse prognostic features, such as Gleason score 7 and above (p = 0.001), seminal vesicle invasion (p = 0.005) and capsular involvement (p = 0.033). On univariate analysis tumors with a PSCA intensity of 3 carried an increased risk of PSA recurrence (p = 0.031, HR 1.77, 95% CI 1.05 to 2.96). However, after adjusting for these variables a PSCA intensity of 3 was no longer an independent predictor of PSA recurrence. Conclusions: We found that high PSCA intensity is significantly associated with adverse prognostic features such as high Gleason score and extra-organ disease. The results of this study suggest that PSCA is a promising tumor marker for the selection of patients at high risk but additional studies are necessary to assess the usefulness of PSCA in patient biopsies.

Original languageEnglish (US)
Pages (from-to)1117-1121
Number of pages5
JournalJournal of Urology
Volume171
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Neoplasm Grading
Seminal Vesicles
Prostate
Prostatic Neoplasms
Stem Cells
Antigens
Prostate-Specific Antigen
Recurrence
Tumor Biomarkers
Prostatectomy
Paraffin
Patient Selection
Monoclonal Antibodies
Staining and Labeling
Biopsy
Survival
Therapeutics

Keywords

  • Mice
  • Prostate
  • Prostate stem cell antigen
  • Prostatic neoplasms
  • Tumor markers, biological

ASJC Scopus subject areas

  • Urology

Cite this

Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer. / Han, Ken Ryu; Seligson, David B.; Liu, Xueli; Horvath, Steve; Shintaku, Peter I.; Thomas, George; Said, Jonathan W.; Reiter, Robert E.

In: Journal of Urology, Vol. 171, No. 3, 03.2004, p. 1117-1121.

Research output: Contribution to journalArticle

Han, Ken Ryu ; Seligson, David B. ; Liu, Xueli ; Horvath, Steve ; Shintaku, Peter I. ; Thomas, George ; Said, Jonathan W. ; Reiter, Robert E. / Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer. In: Journal of Urology. 2004 ; Vol. 171, No. 3. pp. 1117-1121.
@article{4aa5aefff34545e18efac4587e948124,
title = "Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer",
abstract = "Purpose: Few successful therapeutic options exist for men who present with metastatic prostate cancer (CaP) or for the 30{\%} with recurrence. The development and characterization of molecular markers are vital to the development of prognostic and therapeutic modalities in CaP. We investigated the expression and potential clinical usefulness of prostate stem cell antigen (PSCA) in CaP using tissue microarrays. Materials and Methods: Immunohistochemical analysis using a PSCA monoclonal antibody was performed on tissue microarrays constructed from paraffin embedded specimens from 246 patients who underwent radical retropubic prostatectomy. PSCA staining was correlated with established prognostic factors, such as Gleason score, prostate specific antigen (PSA), and seminal vesicle invasion. In addition, recurrence-free survival was analyzed. Results: A high PSCA intensity of 3 was associated with adverse prognostic features, such as Gleason score 7 and above (p = 0.001), seminal vesicle invasion (p = 0.005) and capsular involvement (p = 0.033). On univariate analysis tumors with a PSCA intensity of 3 carried an increased risk of PSA recurrence (p = 0.031, HR 1.77, 95{\%} CI 1.05 to 2.96). However, after adjusting for these variables a PSCA intensity of 3 was no longer an independent predictor of PSA recurrence. Conclusions: We found that high PSCA intensity is significantly associated with adverse prognostic features such as high Gleason score and extra-organ disease. The results of this study suggest that PSCA is a promising tumor marker for the selection of patients at high risk but additional studies are necessary to assess the usefulness of PSCA in patient biopsies.",
keywords = "Mice, Prostate, Prostate stem cell antigen, Prostatic neoplasms, Tumor markers, biological",
author = "Han, {Ken Ryu} and Seligson, {David B.} and Xueli Liu and Steve Horvath and Shintaku, {Peter I.} and George Thomas and Said, {Jonathan W.} and Reiter, {Robert E.}",
year = "2004",
month = "3",
doi = "10.1097/01.ju.0000109982.60619.93",
language = "English (US)",
volume = "171",
pages = "1117--1121",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer

AU - Han, Ken Ryu

AU - Seligson, David B.

AU - Liu, Xueli

AU - Horvath, Steve

AU - Shintaku, Peter I.

AU - Thomas, George

AU - Said, Jonathan W.

AU - Reiter, Robert E.

PY - 2004/3

Y1 - 2004/3

N2 - Purpose: Few successful therapeutic options exist for men who present with metastatic prostate cancer (CaP) or for the 30% with recurrence. The development and characterization of molecular markers are vital to the development of prognostic and therapeutic modalities in CaP. We investigated the expression and potential clinical usefulness of prostate stem cell antigen (PSCA) in CaP using tissue microarrays. Materials and Methods: Immunohistochemical analysis using a PSCA monoclonal antibody was performed on tissue microarrays constructed from paraffin embedded specimens from 246 patients who underwent radical retropubic prostatectomy. PSCA staining was correlated with established prognostic factors, such as Gleason score, prostate specific antigen (PSA), and seminal vesicle invasion. In addition, recurrence-free survival was analyzed. Results: A high PSCA intensity of 3 was associated with adverse prognostic features, such as Gleason score 7 and above (p = 0.001), seminal vesicle invasion (p = 0.005) and capsular involvement (p = 0.033). On univariate analysis tumors with a PSCA intensity of 3 carried an increased risk of PSA recurrence (p = 0.031, HR 1.77, 95% CI 1.05 to 2.96). However, after adjusting for these variables a PSCA intensity of 3 was no longer an independent predictor of PSA recurrence. Conclusions: We found that high PSCA intensity is significantly associated with adverse prognostic features such as high Gleason score and extra-organ disease. The results of this study suggest that PSCA is a promising tumor marker for the selection of patients at high risk but additional studies are necessary to assess the usefulness of PSCA in patient biopsies.

AB - Purpose: Few successful therapeutic options exist for men who present with metastatic prostate cancer (CaP) or for the 30% with recurrence. The development and characterization of molecular markers are vital to the development of prognostic and therapeutic modalities in CaP. We investigated the expression and potential clinical usefulness of prostate stem cell antigen (PSCA) in CaP using tissue microarrays. Materials and Methods: Immunohistochemical analysis using a PSCA monoclonal antibody was performed on tissue microarrays constructed from paraffin embedded specimens from 246 patients who underwent radical retropubic prostatectomy. PSCA staining was correlated with established prognostic factors, such as Gleason score, prostate specific antigen (PSA), and seminal vesicle invasion. In addition, recurrence-free survival was analyzed. Results: A high PSCA intensity of 3 was associated with adverse prognostic features, such as Gleason score 7 and above (p = 0.001), seminal vesicle invasion (p = 0.005) and capsular involvement (p = 0.033). On univariate analysis tumors with a PSCA intensity of 3 carried an increased risk of PSA recurrence (p = 0.031, HR 1.77, 95% CI 1.05 to 2.96). However, after adjusting for these variables a PSCA intensity of 3 was no longer an independent predictor of PSA recurrence. Conclusions: We found that high PSCA intensity is significantly associated with adverse prognostic features such as high Gleason score and extra-organ disease. The results of this study suggest that PSCA is a promising tumor marker for the selection of patients at high risk but additional studies are necessary to assess the usefulness of PSCA in patient biopsies.

KW - Mice

KW - Prostate

KW - Prostate stem cell antigen

KW - Prostatic neoplasms

KW - Tumor markers, biological

UR - http://www.scopus.com/inward/record.url?scp=1542267902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542267902&partnerID=8YFLogxK

U2 - 10.1097/01.ju.0000109982.60619.93

DO - 10.1097/01.ju.0000109982.60619.93

M3 - Article

C2 - 14767283

AN - SCOPUS:1542267902

VL - 171

SP - 1117

EP - 1121

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 3

ER -