Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Shunyou Wang, Jing Gao, Qunying Lei, Nora Rozengurt, Colin Pritchard, Jing Jiao, George Thomas, Gang Li, Pradip Roy-Burman, Peter S. Nelson, Xin Liu, Hong Wu

Research output: Contribution to journalArticle

750 Citations (Scopus)

Abstract

The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.

Original languageEnglish (US)
Pages (from-to)209-221
Number of pages13
JournalCancer Cell
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

Tumor Suppressor Genes
Prostate
Prostatic Neoplasms
Androgens
Prostatic Intraepithelial Neoplasia
Neoplasm Metastasis
Genes
Disease Progression
Adenocarcinoma
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., ... Wu, H. (2003). Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell, 4(3), 209-221. https://doi.org/10.1016/S1535-6108(03)00215-0

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. / Wang, Shunyou; Gao, Jing; Lei, Qunying; Rozengurt, Nora; Pritchard, Colin; Jiao, Jing; Thomas, George; Li, Gang; Roy-Burman, Pradip; Nelson, Peter S.; Liu, Xin; Wu, Hong.

In: Cancer Cell, Vol. 4, No. 3, 01.09.2003, p. 209-221.

Research output: Contribution to journalArticle

Wang, S, Gao, J, Lei, Q, Rozengurt, N, Pritchard, C, Jiao, J, Thomas, G, Li, G, Roy-Burman, P, Nelson, PS, Liu, X & Wu, H 2003, 'Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer', Cancer Cell, vol. 4, no. 3, pp. 209-221. https://doi.org/10.1016/S1535-6108(03)00215-0
Wang, Shunyou ; Gao, Jing ; Lei, Qunying ; Rozengurt, Nora ; Pritchard, Colin ; Jiao, Jing ; Thomas, George ; Li, Gang ; Roy-Burman, Pradip ; Nelson, Peter S. ; Liu, Xin ; Wu, Hong. / Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. In: Cancer Cell. 2003 ; Vol. 4, No. 3. pp. 209-221.
@article{996d6e80a6164f7fbc13dcabb8151b68,
title = "Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer",
abstract = "The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those {"}signature{"} genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.",
author = "Shunyou Wang and Jing Gao and Qunying Lei and Nora Rozengurt and Colin Pritchard and Jing Jiao and George Thomas and Gang Li and Pradip Roy-Burman and Nelson, {Peter S.} and Xin Liu and Hong Wu",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S1535-6108(03)00215-0",
language = "English (US)",
volume = "4",
pages = "209--221",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

AU - Wang, Shunyou

AU - Gao, Jing

AU - Lei, Qunying

AU - Rozengurt, Nora

AU - Pritchard, Colin

AU - Jiao, Jing

AU - Thomas, George

AU - Li, Gang

AU - Roy-Burman, Pradip

AU - Nelson, Peter S.

AU - Liu, Xin

AU - Wu, Hong

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.

AB - The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.

UR - http://www.scopus.com/inward/record.url?scp=10744222860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744222860&partnerID=8YFLogxK

U2 - 10.1016/S1535-6108(03)00215-0

DO - 10.1016/S1535-6108(03)00215-0

M3 - Article

C2 - 14522255

AN - SCOPUS:10744222860

VL - 4

SP - 209

EP - 221

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 3

ER -