Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Shunyou Wang, Jing Gao, Qunying Lei, Nora Rozengurt, Colin Pritchard, Jing Jiao, George V. Thomas, Gang Li, Pradip Roy-Burman, Peter S. Nelson, Xin Liu, Hong Wu

Research output: Contribution to journalArticle

786 Scopus citations

Abstract

The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.

Original languageEnglish (US)
Pages (from-to)209-221
Number of pages13
JournalCancer Cell
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer'. Together they form a unique fingerprint.

  • Cite this

    Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., Liu, X., & Wu, H. (2003). Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell, 4(3), 209-221. https://doi.org/10.1016/S1535-6108(03)00215-0