Prostate cancer survival is dependent on season of diagnosis

Zoya Lagunova, Alina Carmen Porojnicu, Arne Dahlback, Jens Petter Berg, Tomasz M. Beer, Johan Moan

    Research output: Contribution to journalArticle

    46 Scopus citations

    Abstract

    BACKGROUND. We have earlier found that the prognosis for several cancers is dependent on season of diagnosis. More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D. METHODS. The 3 year survival of prostate cancer patients has been analyzed with the Cox regression method for two age groups at different latitudes in Norway. RESULTS. Patients diagnosed during the summer and autumn had the best prognosis (Ralative risk (RR) death 0.8; 95% CI 0.75-0.85). Similar results were observed in three regions of the country that differ with respect to annual fluences of solar UV radiation, incidence rates of squamous cell carcinoma (SCC) and intake of fish. Furthermore, similar relationship between the season and survival was seen among patients ≤65 years and >65 years old, although the younger group had a slightly larger advantage of summer and autumn diagnosis. CONCLUSIONS. The seasonal effect on prognosis maybe related to the seasonal variations of calcidiol (the marker of vitamin D status). The lack of latitude effect and the similarity of prognosis for different age groups may be related to higher consumption of vitamin D in food in the north region and to increase of such consumption with age.

    Original languageEnglish (US)
    Pages (from-to)1362-1370
    Number of pages9
    JournalProstate
    Volume67
    Issue number12
    DOIs
    StatePublished - Sep 1 2007

    Keywords

    • Latitude dependency
    • Prognosis
    • Prostate cancer
    • Seasonal variation
    • Vitamin D

    ASJC Scopus subject areas

    • Oncology
    • Urology

    Fingerprint Dive into the research topics of 'Prostate cancer survival is dependent on season of diagnosis'. Together they form a unique fingerprint.

  • Cite this

    Lagunova, Z., Porojnicu, A. C., Dahlback, A., Berg, J. P., Beer, T. M., & Moan, J. (2007). Prostate cancer survival is dependent on season of diagnosis. Prostate, 67(12), 1362-1370. https://doi.org/10.1002/pros.20577