Prostaglandin involvement in hypothalamic control of gonadotropin and prolactin release

P. G. Harms, S. R. Ojeda, S. M. Mccann

    Research output: Contribution to journalArticle

    91 Scopus citations

    Abstract

    Prostaglandin E2 (PGE2) injected into the third ventricle of ovariectomized rats increased plasma luteinizing hormone dramatically and follicle stimulating hormone slightly. PGE1 elevated prolactin; PGF or PGF had no effect. PGE2 or PGE1 injected directly into the anterior pituitary were ineffective. These results suggest that specific prostaglandins act at the hypothalamus to control pituitary hormone release.

    Original languageEnglish (US)
    Pages (from-to)760-761
    Number of pages2
    JournalScience
    Volume181
    Issue number4101
    DOIs
    StatePublished - Jan 1 1973

    ASJC Scopus subject areas

    • General

    Fingerprint Dive into the research topics of 'Prostaglandin involvement in hypothalamic control of gonadotropin and prolactin release'. Together they form a unique fingerprint.

  • Cite this