Prostaglandin induced release of pituitary gonadotropins

central nervous system and pituitary sites of action

P. G. Harms, Sergio Ojeda, S. M. McCann

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Prostaglandins were injected either intravenously, intraventricularly, or into the anterior pituitary gland to evaluate their possible participation in the control of gonadotropin release. Their effect on plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) was determined by radioimmunoassay. Intravenous injection of prostaglandin E2 (PGE2) produced a slight increase in plasma LH but not FSH in ovariectomized rats. Prostaglandin E1 (PGE1), PGF1(α) and PGF2(α) were ineffective. Third ventricular (3rd V) injections of PGE2 induced a marked increase in plasma LH in ovariectomized rats. The increase was much greater than that observed following iv injection, and PGE1, F1(α) or F2(α) were ineffective. A slight increase in plasma FSH also followed 3rd V injection of PGE2. Ovariectomized animals were injected SC 48 hr prior to the experiment with estradiol benzoate (10 μg) to sensitize the pituitary gland to the gonadotropin releasing factor(s). In these animals 3rd V injections of PGE2 produced a dose related increase in plasma LH. In addition, a significant increase was also obtained with PGE1. The other prostaglandins and the diluent were again ineffective. Intrapituitary injections of PGE2 and E1 were ineffective in ovariectomized animals, but PGE2 produced a small increase in LH in estrogen primed rats. The results indicate that PGE2 and, to a lesser extent, PGE1 have a specific effect in stimulating the release of LH by the adenohypophysis. The principal site of action appears to be on the central nervous system (CNS) with another less important site on the anterior pituitary itself. The findings suggest that PGE2 and possibly PGE1 are involved in neural control of pituitary gonadotropin release.

Original languageEnglish (US)
Pages (from-to)1459-1464
Number of pages6
JournalEndocrinology
Volume94
Issue number5
StatePublished - 1974
Externally publishedYes

Fingerprint

Pituitary Gonadotropins
Dinoprostone
Prostaglandins
Alprostadil
Central Nervous System
Luteinizing Hormone
Follicle Stimulating Hormone
Injections
Anterior Pituitary Gland
Dinoprost
Gonadotropins
Pituitary Gland
Intravenous Injections
Radioimmunoassay
Estrogens

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Prostaglandin induced release of pituitary gonadotropins : central nervous system and pituitary sites of action. / Harms, P. G.; Ojeda, Sergio; McCann, S. M.

In: Endocrinology, Vol. 94, No. 5, 1974, p. 1459-1464.

Research output: Contribution to journalArticle

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