Prostaglandin-Independent Inhibition of Ocular Vascular Permeability by a Platelet-Activating Factor Antagonist

Richard M. Rubin, John R. Samples, James T. Rosenbaum

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Platelet-activating factor (PAF), a lipid mediator of inflammation, may markedly increase vascular permeability. We assessed the ability of the PAF antagonist SRI 63-441 to inhibit ocular vascular permeability induced by the intravenous injection of endotoxin or anterior chamber paracentesis. The PAF antagonist SRI 63-441 significantly blocked ocular vascular permeability following either intravenous endotoxin or anterior chamber paracentesis as determined by the reduction in accumulation of 70 000-molecularweight fluorescein isothiocyanate—conjugated dextran or serum proteins into the anterior chamber. SRI 63-441 did not reduce increases in aqueous humor prostaglandin E2 levels. The efficacy of the PAF antagonist was additive in combination with either topical indomethacin or topical corticosteroid. Combined therapy almost completely prevented increases in ocular vascular permeability. These data support the conclusion that multiple mediators contribute to ocular vascular permeability and that combinations of pharmacologic agents may be superior to a single drug.

Original languageEnglish (US)
Pages (from-to)1116-1120
Number of pages5
JournalArchives of ophthalmology
Volume106
Issue number8
DOIs
StatePublished - Aug 1988

ASJC Scopus subject areas

  • Ophthalmology

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